The game featured a pitching matchup between two of the top young left-handed arms in baseball, with Oakland's Brett Anderson and Arizona's Tyler Skaggs on the mound. Eight pitches into the first inning, however, Anderson left the game with a strained right trapezius.
Skaggs on the other hand tossed four innings Sunday, allowing four runs on four hits.
"Numbers mean nothing to me; it's all about how you feel and what the coaches see," Skaggs said. "Spring Training is a confidence booster, and today added to my confidence out there. I felt like I was throwing the ball well."
The D-backs got the scoring started in the first inning when A.J. Pollock singled to center to drive in a run after Adam Eaton scored on a wild pitch.
The A's tied the game an inning later on a Michael Choice infield single, then took the lead for good in the third when Lowrie hit a two-run blast to left-center field off Skaggs.
"I was just trying to get ahead, and he put a good swing on it," Skaggs said. "I wasn't trying to overpower him, just challenge him."
Lowrie added his third RBI of the day in the fifth to extend the Oakland lead.
Also pitching Sunday for the A's was Bartolo Colon, who threw three innings, surrendering one run on four hits.
D-backs up next: The D-backs return to Salt River Fields on Monday to host the Cubs at 1:10 p.m. MST. Trevor Cahill will start for the D-backs, making it his second time facing the Cubs this spring. David Holmberg, one of the D-backs' top pitching prospects, and Josh Collmenter are also scheduled to pitch.