Cashner, who signed with the O's as a free agent in the early days of Spring Training, won his second start of the season. Since then, he has had four losses and three no-decisions.
"It can't go this bad the whole season," Cashner said. "You can get frustrated and get down, but you just have to trust the process and keep going."
Orioles manager Buck Showalter was happy with what he saw from Cashner.
"Cash pitched well. We just didn't score," Showalter said. "We had one run and, what, four hits? … For us, that's where it lies for me. Just didn't do a whole lot, and the balls we did hit hard were in the wrong places."
The Orioles won five of their eight games on their homestand, their first winning one of the season. They now have an 11-game road trip to play the Red Sox, White Sox and Rays.
"It's nice that we're building on something," Jones said. "I think we swung the bats on this homestand really, really well, so let's just try and build on that and keep swinging the bats in Boston and Chicago and Tampa, but let's start tomorrow in Boston and keep the bats hot. Keep the same approach we had the last couple of days and just try and barrel the ball up -- not try and hit the ball too far, but hit the ball hard."
Jones' home run was the only offense the O's could muster. The Phillies took control in the sixth, scoring three runs. Cesar Hernandez hit his fifth home run of the year, leading off against Cashner to tie the score at 1. Run-scoring singles by Maikel Franco and Pedro Florimon gave the Phils a 3-1 lead.
In the seventh, Hernandez's one-out triple was followed by Rhys Hoskins' double to make it 4-1.
MOMENTS THAT MATTERED The Orioles had two of their four hits in the eighth. Trailing by three runs, Chance Sisco singled, and with out out, Jace Peterson doubled against former Oriole Tommy Hunter. With runners on second and third, Luis Garcia walked Trey Mancini to load the bases, but Jones flied to short center and Machado grounded to short, ending the threat.
SOUND SMART The Orioles were held to four hits, the ninth time in 42 games they've had four or fewer hits. Not surprisingly, they've lost all nine of those games.
HE SAID IT "I like the fact that he goes after hitters. He's not afraid. He pumps everybody up on the bench. He's into the game, if he's starting or not. The energy that he brings on an daily basis is contagious. That's something that I love to see, especially out of the starters. Get everybody up, even when it's not their turn to pitch." -- Jones, on what he likes about Cashner
UP NEXT Kevin Gausman takes the mound as the Orioles begin a four-game series with the Red Sox at Fenway Park on Thursday. Gausman (3-2, 3.18 ERA) -- who allowed a career-high 11 hits, but only two runs, in his last outing -- hasn't lost in his past three starts. Game time is 7:10 p.m. ET. David Price goes for Boston.