"He pulled something, felt something in the back of his leg and we'll check it out [Friday]," White Sox manager Robin Ventura said.
Tyler Saladino replaced Lawrie at second base. Lawrie, who's hitting .248 with 12 home runs and 36 RBIs in his first season with the White Sox, said it was a precautionary measure to come out of the game. He felt a twinge before the game and it didn't subside enough for him to continue.
"It's one of those things where you take care of it, because we've got  games left, so it's important to be ready for those and not necessarily worry about just today," he said. "You've got to look forward as well."
Chicago currently has seven players on the disabled list, including starting pitcher Carlos Rodon, center fielder Austin Jackson, catcher Alex Avila and reliever Zach Putnam.
Brian Hedger is a contributor to MLB.com based in Chicago.