Dexter Fowler started the rally by reaching on an error from second baseman Brian Dozier on a play that was originally ruled as a hit. Anthony Rizzo followed with a single to center with Fowler going to third base. After a flyout to center from Kris Bryant that advanced Rizzo, the Twins intentionally walked Chris Coghlan to get to Castro. Castro hit the first pitch from Boyer to center field to score both Fowler and Rizzo. Chris Denorfia added a bloop RBI single to right with two outs to give Chicago an insurance run.
Twins right-hander Trevor May and Cubs left-hander Jon Lester both pitched well, but neither factored into the decision. May gave up one run on seven hits over six frames, while Lester allowed one run on just three hits over 6 1/3 innings.
"Both starters did well," Twins manager Paul Molitor said. "Trevor hung in there. He got out of a big bases-loaded jam and found a way to minimize through six innings. And from there, it just became a three-inning game for both teams with a lot of chances on both sides, but they finally capitalized there."
Lester's lone mistake came in the third inning on a solo shot from Kurt Suzuki. The Cubs scored their one run against May in the third on an RBI double down the left-field line from Rizzo. The Twins had several scoring chances late, but recorded three outs on the basepaths over the eighth and ninth innings.
MOMENTS THAT MATTERED Consistent Lester: For the second straight outing, Lester gave up one run but did not get a decision. The lefty was pulled after throwing 102 pitches over 6 1/3 innings, and he tried to convince manager Joe Maddon to leave him in. Lester struck out seven and scattered three hits, including Suzuki's homer. He is winless in his last six starts.
"I never [want to come out]," Lester said. "That's the way I've always been. I don't want to leave games. That's why you have managers and pitching coaches to make those decisions for you. I may not be happy at the time, but I'll never second-guess the manager on what he's trying to do."
Maddon didn't want Lester to face Suzuki again, which is why he pulled the lefty when he did. And the manager explained that to Lester in the dugout.
"The explanation was nice, and it always eases your mind when you get an explanation," Lester said.
Baserunning costs Twins:Top prospectByron Buxton drew his second walk of the game to lead off the eighth inning, but he was thrown out by Fowler trying to tag up on a ball hit to the warning track in center field. Eddie Rosario followed with a single, but he was picked off at first by catcher David Ross to end the inning. The Twins made another out in the ninth, when Joe Mauer led off with a walk but was thrown out at second on a stolen-base attempt on a play that was reversed after a review.
"We had some chances," Molitor said. "Buxton did a good job trying to tag up on that ball, but he got locked in with his foot it appeared. And we had a base stolen, but just couldn't hold onto the base. So little things like that make a difference in a ballgame." More >
Rizzo delivers: With two outs in the Cubs third, Addison Russell and Fowler both singled to set up Rizzo, who fell behind, 0-2, to May before lining an RBI double to left. Rizzo ranks among the top five in the NL in batting with an 0-2 count, as he now is 7-for-20.
Suzuki goes deep: Suzuki hadn't homered since April 18, but he jumped on a first-pitch fastball from Lester in the second inning to give the Twins an early 1-0 lead. It was the third homer of the year for Suzuki to match his total from last year.
May gets out of jam: With runners at the corners and nobody out in the sixth, May struck out Castro and Kyle Schwarber before walking Denorfia to load the bases with two outs. But May picked up his third strikeout of the inning to escape unscathed, as he was able to punch out David Ross on an 0-2 changeup to leave the bases loaded.
"I tried to stay mentally focused pitch to pitch," May said. "I was acutely aware of trying to make my pitches move a certain way or to try to hit my spots."
"The pitch was where it needed to be. It stinks. I hate that we're battling and I was the cause of the loss." -- Boyer, on giving up the go-ahead two-run single to Castro
"It just goes back to forgetting about what happened last night. You worry about today today. It's nice to see that from the young guys. Guys continue to grind, guys continue to battle. You'd never know what happened yesterday." -- Lester, on Castro and the Cubs rebounding from Friday's loss
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Cubs rookie Bryant went 0-for-4 on Saturday, and it's the first time he's gone hitless in back to back games since April 29-May 3.
Mauer walked to open the Twins' ninth and was credited with a stolen base, but the Cubs challenged the call and after a review, it was overturned. Catcher Miguel Montero threw to rookie second baseman Russell, who made a nice tag on the play.
"You're not expecting Mauer to run," Maddon said. "He had the base stolen. We talked about it all camp about keeping the tag on the runner, and Addison did, thus, he's out. [The review] is part of technology, part of the new rules, but then you have to technique-wise incorporate it, which we did."
WHAT'S NEXT Cubs:Jake Arrieta will close the Cubs' Interleague series against the Twins on Sunday. The right-hander is coming off a loss to the Indians in which he walked six batters.This also will be Schwarber's last game before he heads back to the Minor Leagues. Schwarber was called up from Double-A Tennessee to be the designated hitter in five games, and he will join Triple-A Iowa on Monday. First pitch Sunday will be 1:10 p.m. CT.
Twins: Right-hander Kyle Gibson takes the mound for the Twins in the series finale on Sunday afternoon at 1:10 p.m. CT. Gibson had a 1.36 ERA in six starts in May, but he has a 5.68 ERA in three starts in June.