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The players listed below could provide difference-making stats for DraftKings participants on Saturday.
David Ortiz: In his legendary career, the slugger has posted an impressive .295/.398/.584 slash line against right-handers. Ortiz could add to his impressive 2016 totals of 18 homers and 60 RBIs across 281 plate appearances when he faces fly-ball-prone righty A.J. Griffin (career 1.4 HR/9 rate) and a Rangers bullpen that ranks 28th in baseball with a 4.63 ERA.
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Mike Trout: With a lifetime .285/.395/.516 slash line against left-handers, the outfielder has proven to be among the best in baseball during those matchups. Trout could post a substantial DraftKings total when he faces A's southpaw Dillon Overton, who will be making his first career start.
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Albert Pujols: Hitting .230 this season, the first baseman has continued to flash his power stroke by compiling 12 homers and 45 RBIs across 269 at-bats. Pujols could excel when he brings his lofty lifetime .313/.403/.600 slash line against left-handers into a matchup with the inexperienced Overton.
Colby Rasmus: With a lifetime .783 OPS against right-handers that exceeds his .668 mark vs. lefties, the powerful outfielder could put a ball into the outfield seats when he faces Royals fly-ball-prone righty Chris Young (5.61 ERA, 1.42 WHIP, 3.3 HR/9 rate in 2016).
Jason Kipnis: From a premium lineup spot, the second baseman could excel when he takes his lifetime .809 OPS against right-handers (.656 vs. lefties) into a matchup with righty Anibal Sanchez (5.97 ERA, 1.60 WHIP in 2016) and a Tigers bullpen that ranks 27th in the Majors with a 4.57 ERA.
Brian McCann: One of the most powerful catchers in baseball, the left-handed-hitting McCann could go deep when brings his lifetime .821 OPS against right-handers (.752 vs. lefties) into a home matchup against Twins right-hander Ervin Santana (career 4.18 ERA, 1.29 WHIP, 1.2 HR/9 rate). Also working in McCann's favor: Yankee Stadium is especially power-inducing for lefty batters.
Didi Gregorius: The shortstop owns notable lifetime splits, with a .722 OPS against right-handers in comparison to a .611 mark vs. lefties. Gregorius -- who is hitting .342 in June -- could provide cost-effective production at a premium position when he faces the right-handed Santana (4.83 ERA, 1.43 WHIP in 2016) and a Twins bullpen that ranks 29th in the Majors with a 4.67 ERA.
Edwin Encarnacion: Hitting .303 with nine homers and 22 RBIs across 66 at-bats in June, Encarnacion will bring a red-hot bat into a matchup with fly-ball-prone righty Miguel Gonzalez (career 4.65 FIP, 1.3 HR/9 rate) at homer-happy U.S. Cellular Field.
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Michael Saunders: Hitting .304 with 15 homers across 237 at-bats, the outfielder has been a cost-effective option in many 2016 DraftKings contests. Saunders could go deep or drive in multiple runs when he brings his lifetime .731 OPS against right-handers (.684 vs. lefties) into a matchup with the homer-prone righty Gonzalez (4.29 ERA, 1.45 WHIP in 2016) at Chicago's hitter-friendly venue.
Addison Russell: The second-year shortstop has produced pronounced lifetime splits, with a .760 OPS against right-handers that exceeds his .521 mark vs. lefties. Russell could reach base often or drive in multiple runs when he faces Marlins righty Paul Clemens (career 5.50 ERA, 1.54 WHIP).
Jason Heyward: From the No. 2 spot in a talent-laden Cubs lineup, Heyward could reach base often or score multiple runs when he brings his lifetime .823 OPS against right-handers (.663 vs. lefties) into a matchup with the right-handed Clemens (career 6.17 FIP, 2.1 HR/9 rate).
Paul Goldschmidt: With a lifetime .336/.437/.602 slash line against left-handers, the first baseman has proven to wield a potent bat during those matchups. Goldschmidt -- who is hitting .359 in June -- could post a difference-making DraftKings total when he faces southpaw Jorge De La Rosa (career 4.64 ERA, 1.44 WHIP) at homer-happy Coors Field.
Welington Castillo: With a lifetime .873 OPS against left-handers that exceeds his .682 mark vs. righties, Castillo could provide production at a premium position when he bats at Colorado's hitter-friendly park against the left-handed De La Rosa (7.17 ERA, 1.62 WHIP in 2016). In his career, De La Rosa has allowed right-handed hitters such as Castillo to post a .798 OPS (.642 OPS allowed to lefty batters).
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Yasmany Tomas: In his career, the right-handed-hitting outfielder has posted an .899 OPS against left-handers in comparison to a .654 mark vs. righties. Tomas could be part of a high-scoring lineup on Saturday, as the D-backs lead the Majors with an .839 OPS against southpaws such as De La Rosa.
Chris Tillman: Having produced a 3.11 ERA and a 1.15 WHIP across 15 starts, the right-hander is in the midst of a bounceback season. Tillman could continue his successful campaign when he faces a Rays lineup that ranks 24th in the Majors in OPS vs. righties (.698) and fifth in baseball with 654 total strikeouts.
Madison Bumgarner: With a 1.85 ERA and a 1.02 WHIP this season, the left-hander continues to rank among the most consistent aces in baseball. Bumgarner could post a memorable DraftKings total when he works at his pitcher-friendly home park against a Phillies lineup that ranks 29th in the Majors with a .602 OPS against southpaws.
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Jacob deGrom: With a lifetime 2.67 ERA and a 1.06 WHIP, the right-hander ranks among the most effective starters in the Senior Circuit. deGrom could deliver a stellar start when he faces a Braves lineup that ranks 29th in the Majors in OPS against righties (.660) and last in total home runs (34).
All statistics are accurate through the completion of Thursday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB