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The players listed below could provide difference-making stats for DraftKings participants on Saturday.
Daniel Murphy: Hitting .394, the second baseman has been one of the most productive players at his premium position this season. Batting out of the cleanup spot, Murphy could reach base often or drive in multiple runs when he brings his lifetime .801 OPS against right-handers (.689 vs. lefties) into a matchup with righty Dan Straily (career 4.38 ERA, 1.29 WHIP) and a Reds bullpen that ranks last in the Majors with a 6.62 ERA.
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Chris Davis: Since the outset of 2013, the left-handed-hitting first baseman has used a patient, powerful approach to build a .258/.370/.574 slash line against right-handers. Davis could go deep when he hits at home against Yankees righty Ivan Nova (career 4.31 ERA, 1.38 WHIP), as Camden Yards is especially power-enhancing for lefty batters.
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Jonathan Schoop: One of the most powerful second basemen in baseball, Schoop has hit 20 homers across 357 at-bats against right-handers since the outset of 2015. He could rip a round-tripper or drive in multiple runs when he tangles with the righty Nova (career 4.31 FIP).
Manny Machado: With 49 homers, 20 steals, 120 RBIs and 141 runs since the outset of 2015, the third baseman has emerged as one of the most productive players in baseball. Machado could contribute to DraftKings lineups in multiple ways when he faces Nova on Saturday.
Corey Seager: Since debuting on Sept. 3, 2015, Seager has posted an impressive .292/.358/.486 slash line against right-handers. The shortstop could have a great game at the expense of Braves righty Bud Norris, who in his career has allowed left-handed batters such as Seager to post an .817 OPS (.711 OPS allowed to righty batters).
Adrian Gonzalez: In his career, the first baseman has registered an .899 OPS against right-handers that exceeds his .769 mark vs. lefties. As a left-handed hitter set to face the righty Norris (career 4.49 ERA, 1.41 WHIP) and a Braves bullpen that ranks 24th in the Majors with a 4.23 ERA, Gonzalez could post a notable total in DraftKings contests.
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Franklin Gutierrez: The outfielder has produced pronounced lifetime splits, with an .840 OPS against left-handers that exceeds his .659 mark vs. righties. Gutierrez could thrive when he vacates his pitcher-friendly home park and bats at offense-inducing Globe Life Park in Arlington against southpaw Martin Perez (career 4.01 ERA, 1.39 WHIP).
Chris Iannetta: The catcher will be poised to provide cost-effective production at a premium position when he brings his lifetime .859 OPS against left-handers (.704 vs. righties) into a matchup with the lefty Perez at Texas' hitter-friendly venue. Iannetta could also thrive late in the game against a Rangers relief corps that ranks 29th in baseball with a 5.10 ERA
Nelson Cruz: The only player to reach the 40-homer mark in each of the previous two seasons, the outfielder could go deep when he brings his impressive lifetime .299/.375/.548 slash line against left-handers into a matchup with the southpaw Perez and an unreliable Rangers relief corps. In his career, Perez has allowed right-handed hitters such as Cruz to post a .761 OPS (.639 OPS allowed to lefty batters).
Corey Dickerson: Hitting .199 this season, the outfielder could have a reduced price tag in DraftKings contests when he brings his impressive lifetime .912 OPS against right-handers (.614 vs. lefties) into a matchup with Twins righty Ervin Santana (career 4.16 ERA, 1.29 WHIP). Also of note: Dickerson will put the ball into play against a Twins squad that ranks last in the Majors with a .661 defensive efficiency ratio.
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Eric Hosmer: Since the outset of 2015, the first baseman has posted a game-changing .329/.396/.531 slash line against right-handers. From the heart of the lineup, Hosmer could rip a round-tripper when he faces Indians fly-ball-prone righty Josh Tomlin (career 1.5 HR/9 rate).
Kendrys Morales: Hitting .197 this season, the slugger could have a reduced cost in DraftKings contests when he faces the homer-prone righty Tomlin (1.6 HR/9 rate in 2016). In his career, Morales has posted an .803 OPS against right-handers that exceeds his .740 mark vs. lefties.
Dexter Fowler: From his perch atop a talented Cubs lineup, the outfielder could reach base often or score multiple runs when he brings his lifetime .828 OPS against left-handers (.775 vs. righties) into a matchup with D-backs southpaw Edwin Escobar. The lefty hurler allowed seven earned runs (eight total) across 3 1/3 innings in his only career start.
Chris Sale: With a 9-1 record, a 2.29 ERA and a 0.88 WHIP, the left-hander has been arguably the most effective starter in the American League this season. The owner of a lifetime 2.86 ERA and a 10.2 K/9 rate, Sale could excel against a Tigers lineup that ranks 21st in baseball with a .696 OPS against southpaws.
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Stephen Strasburg: Having produced a 2.69 ERA and a 1.09 WHIP this season, the right-hander has been one of the most effective starters in the Senior Circuit. Strasburg could compile a handful of effective innings and whiffs when he brings his impressive lifetime 10.5 K/9 rate into a matchup with a Reds lineup that ranks 23rd in baseball with a .700 OPS against righties.
Clayton Kershaw: With a 1.97 ERA, a 0.82 WHIP and an 11.4 K/9 rate since the outset of 2015, the left-hander has left little argument that he is the most dominant starter in baseball. Kershaw could post a memorable total in DraftKings contests when he works at home against a Braves lineup that ranks last in baseball in OPS against southpaws (.573) and total home runs (22).
All statistics are accurate through the completion of Friday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB