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The players listed below could provide difference-making stats for DraftKings participants on Thursday.
Jay Bruce: Bruce has traditionally fared best vs. right-handers, against whom he has a lifetime .813 OPS (.718 vs. lefties). The outfielder could go deep or drive in multiple runs when he tangles with Rockies righty Eddie Butler (career 5.55 ERA, 1.63 WHIP), who in his career has allowed left-handed hitters such as Bruce to post a 1.021 OPS (.790 OPS allowed to righty batters).
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Joey Votto: The first baseman has used a patient, powerful approach to post a lofty lifetime .312/.430/.542 slash line against right-handers. Votto will be in prime position to excel when he bats at Colorado's offense-inducing venue against the right-handed Butler (4.13 ERA in 2016) and a Rockies relief corps that ranks 24th in baseball with a 4.42 ERA.
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Carlos Gonzalez: In his career, the outfielder has fared best when facing right-handers (career .304/.368/.563 slash line) and batting at his hitter-friendly home park (lifetime .331/.391/.624 line). Gonzalez could have a terrific game when he hits at home against Reds righty Alfredo Simon (career 4.46 ERA, 1.38 WHIP).
Charlie Blackmon: As a big leaguer, the speedy outfielder has posted a .793 OPS against right-handers that exceeds his .739 mark vs. lefties. Hitting leadoff, Blackmon may maximize his opportunities to reach base and score runs when he tangles with the righty Simon (9.60 ERA, 2.06 WHIP in 2016) and a Reds relief corps that ranks last in the Majors with a 6.76 ERA.
Gerardo Parra: In his career, Parra has registered a .764 OPS against right-handers that exceeds his .613 mark vs. lefties. The outfielder could excel when he bats at his hitter-friendly home park against the right-handed Simon and an unreliable Reds relief corps.
Logan Morrison: The first baseman will be poised to rip a round-tripper when he brings his lifetime .756 OPS against right-handers (.687 vs. lefties) into a matchup with righty Phil Hughes. Also of note: Morrison will attempt to put balls into play against a Twins squad that ranks last in the Majors with a .662 defensive efficiency ratio.
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Christian Yelich: From the No. 3 spot in the lineup, Yelich could have a great game when he brings his lifetime .820 OPS against right-handers (.700 vs. lefties) into a matchup against Pirates righty Juan Nicasio (career 4.87 ERA, 1.46 WHIP). The outfielder could also swipe a base against Francisco Cervelli, who has allowed more steals than any other catcher since the outset of 2015.
Derek Dietrich: With a lifetime .797 OPS against right-handers that exceeds his .648 mark vs. lefties, the second baseman will be in prime position to display his power when he tangles with the right-handed Nicasio (4.79 ERA, 1.38 WHIP in 2016).
David Ortiz: Much of the slugger's impressive career resume can be traced to his lofty lifetime .294/.397/.582 slash line against right-handers. Hitting .335 with 14 homers and 47 RBIs this season, Ortiz may post a game-changing DraftKings total when he bats at hitter-friendly Camden Yards against righty Ubaldo Jimenez (career 4.09 ERA, 1.38 WHIP).
Travis Shaw: The third baseman will be in great position to improve on his lifetime .281/.351/.482 slash line against right-handers when he faces the righty Jimenez (6.36 ERA, 1.87 WHIP in 2016) at Camden Yards, which has proven to be especially homer-happy for left-handed hitters such as Shaw.
Mookie Betts: Hitting atop a Red Sox lineup that leads the Majors in runs, Betts has compiled 12 homers, eight steals, 49 runs and 40 RBIs across 246 plate appearances this season. The outfielder could contribute to DraftKings squads in multiple ways when he tangles with Jimenez at offense-inducing Camden Yards.
Robinson Cano: Hitting .291 with 15 homers and 45 RBIs across 206 at-bats, the second baseman has been one of the most productive players at his premium position this season. Cano could post a game-changing DraftKings total when he faces righty Colin Rea (career 4.39 ERA, 1.33 WHIP) and a Padres bullpen that ranks 27th in baseball with a 4.64 ERA.
Brian Dozier: Hitting .202 this season, the second baseman could come at a discount in DraftKings contests when he faces Rays southpaw Matt Moore (5.31 ERA, 1.47 WHIP in 2016). As a big leaguer, Dozier has posted an .831 OPS against left-handers that exceeds his .679 mark vs. righties.
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Derek Norris: With a lifetime .838 OPS against left-handers in comparison to a .631 mark vs. righties, the catcher will be poised to provide production at a premium position when he meets up with Mariners southpaw Wade Miley (4.95 ERA, 1.32 WHIP in 2016).
Chase Anderson: The right-hander owns a 5.00 ERA and a 1.35 WHIP this season, but he has produced a 3.28 ERA and a 0.77 WHIP across his past four starts. Anderson could continue his recent run of success when he faces a Phillies lineup that ranks 28th in the Majors with a .657 OPS against righties.
Carlos Carrasco: With a 3.13 ERA, a 1.03 WHIP and a 10.0 K/9 rate since the outset of 2014, the right-hander has the skills to post a difference-making DraftKings total when he works at home against a Royals lineup that will operate without injured regulars Alex Gordon and Mike Moustakas. Carrasco could combine a handful of effective innings with a win if his supporting cast has success against Yordano Ventura (5.17 ERA, 1.53 WHIP in 2016).
Matt Boyd: Despite owning a lifetime 6.85 ERA and a 1.52 WHIP across 67 innings, Boyd should be considered as a cost-effective second starter in DraftKings contests when he works at home against a Yankees lineup that ranks 26th in the Majors with a .662 OPS against southpaws.
All statistics are accurate through the completion of Tuesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB