Rosario's 354-foot shot left his bat at 97.7 mph, according to Statcast™, and sailed over the right-field wall.
The 26-year-old outfielder, who drove in four and finished 2-for-5 on Saturday, is now sitting just outside the American League top 10 in homers -- Rangers outfielder Joey Gallo and Yankees slugger Giancarlo Stanton were tied for 10th at 18 apiece coming into Saturday.
The Twins elected to rest Rosario on Thursday to nurse his sore right shoulder. Twins manager Paul Molitor said that as long as the injury doesn't get worse, Rosario will attempt to play through it and rest when needed.
"I think if he has to make a throw, he'll do it." Molitor said before Saturday's game.
Jarrid Denney is an reporter for MLB.com based in Minneapolis.