It appeared Weeks was going to reach first with no one covering the bag, but his right leg revolted about three-quarters of the way down the line. Weeks was unable to rise and was tagged out by Bartolo Colon.
"It looks like [Weeks] is going on the DL," Padres manager Andy Green said. "It looks like he got it pretty good."
Jay Paris is a contributor for MLB.com based in San Diego.