The victory, coupled with Toronto's loss, gives the O's sole possession of first place in the American League East by one game. It also came on a day that Machado watched his mentor, Yankees infielder Alex Rodriguez, announce the end of his playing days in a press conference.
"You got people young in your life that have time for you back when you weren't who you are now, so to speak. Everybody was watching intently," manager Buck Showalter said of Rodriguez. "He's been a big part of the Major Leagues for a long time. I'm sure Manny had some emotion, but he really took it out there on the field with him."
The Orioles unloaded on White Sox starter James Shields, as Machado's first two homers helped chase the righty after just four outs. J.J. Hardy and Chris Davis also went deep, with Davis' blast following Machado's second one to complete a back-to-back effort.
"I threw 35, 36 pitches -- whatever it was in the first inning. Anytime you do that, you're going to tax yourself," Shields said. "Bundy did a good job of going 1-2-3 with  pitches and I went back out and just didn't do my job."
Machado's home run off Matt Albers in the third made him the first Orioles batter since Davis in 2014 to turn in a three-homer game. Machado now has 25 homers on the season and eight career multihomer games.
O's rookie starter Dylan Bundy went six innings, struck out nine and allowed two runs, including Jose Abreu's sixth-inning solo homer. The White Sox also scored on Todd Frazier's sacrifice fly in the fourth.
"Once we got down that much, it was going to be hard to come back because Bundy was just as tough on the other side," White Sox manager Robin Ventura said. "That's probably some of the best stuff we've seen all year."
MOMENTS THAT MATTERED Mashin' Manny: Machado highlighted quite the homer parade for the O's. The third baseman, who has 67 RBIs, had the most oomph on his first homer. He blasted Shields' pitch an estimated 417 feet with an exit velocity of 103 mph, according to Statcast™. Machado's other homers went 369 feet and 402 feet, respectively.
"It was awesome. Any time you hit a home run, it's great," Machado said. "It hasn't been the greatest the last couple of weeks trying to find my swing. Been working quite a bit in the cage and outside, so finally some work paid off today." More >
Eaton does it again:Adam Eaton hasn't lost his Gold Glove touch in right field, despite seeing some time in center recently. Eaton took a two-run homer away from Matt Wieters in the second when he caught the catcher's towering drive with a leap at the top of the right-field wall.
Bundy passes another test: The righty continues to provide a solid starting option for an Orioles rotation that has struggled most of the year. Bundy recorded a career-high nine strikeouts, holding Chicago to four hits and a walk in his second consecutive quality start.
"I really had to remind myself in the fifth to make sure I focused, even though I had a nine-run lead," Bundy said. "It's hard. You're in the dugout for 20 minutes or so while these guys are hitting homers, but I'll take that any day."
Rejuvenated Abreu: Jose Abreu homered for the third time in four games and hit his second blast of this three-game home series. He doubled in the second and singled in the fourth, falling a triple short of hitting for the cycle.
"Just his hands. It's always his hands working, but it's going to also be pitch selection and his aggressiveness," Ventura said of Abreu, who was homerless in his previous 32 games from June 25-Aug. 3 before this power outburst. "He just looks better.
"The way his bat's coming through the zone, it's a little quicker. Even though guys are going to continue to pitch him inside just like everybody else, he's able to get to it, he's able to still be on time, balance-wise, to be able to hit the outside pitch, too."
QUOTABLE "Veteran guys will do that. When they feel like they're not doing their part, they yell into their glove a lot." -- Ventura, on Shields' angry mound reaction to his Sunday struggles
"Ubaldo [Jimenez] giving us three big innings there, we really need that. Guess he got a save, but he saved a lot of other things. That was a great team contribution by Ubaldo today." -- Showalter, on Jimenez going three innings
SOUND SMART WITH YOUR FRIENDS Machado is just the second player in Major League history to hit a home run in the first, second and third inning of the game. The other was Carl Reynolds of the White Sox on July 2, 1930, at the Yankees, according to Stats. Machado is the ninth player in MLB history to hit a homer in three consecutive innings at any point during the game.
The White Sox are 0-6-2 in their last eight season-series matchups with Baltimore.
PEARCE LIFTED Orioles outfielder Steve Pearce exited Sunday's game after four innings with a right elbow strain. Pearce, who was acquired on Monday's non-waiver Trade Deadline, received a cortisone shot and was optimistic he would be able to avoid the disabled list. More >
WHAT'S NEXT Orioles:Kevin Gausman will take the mound for Monday's start of a four-game series at 10:05 p.m. ET in Oakland. Gausman was much improved in his last outing against the Rangers, in which he struck out seven and held a lethal Texas lineup to two runs in the win.
White Sox:Chris Sale takes the mound on Tuesday against the Royals at 7:15 p.m. CT at Kauffman Stadium to begin a nine-game road trip for the White Sox, making his fifth attempt at win No. 15. The five-time All-Star picked up his fourth complete game this season in a loss to Detroit last Wednesday.