Dustin Pedroia, who has been red-hot of late, had to sit out with left knee soreness, and left fielder Hanley Ramirez aggravated his mid-back in Monday's 4-2 loss to Atlanta. Boston got the job done without the duo, securing a 9-4 win.
Manager John Farrell hopes to have both players back in the lineup by Wednesday night in Atlanta.
Over his past 14 games, Pedroia is hitting .397 with a 1.005 OPS.
"Pedey's got some left knee soreness that stems from a collision at second base a couple of days ago," said Farrell. "There's a little bit of fluid buildup in there. We're taking precautions with him. Well, he came in to get treatment, wanted to [play]. At the strong recommendation of the medical staff, it was a day needed off his feet."
Brock Holthit for the cycle while filling in for Pedroia in the leadoff spot and at second base, and shortstop Xander Bogaerts batted cleanup. Alejandro De Aza made the start in left field.