FORT MYERS, Fla. -- The Twins will start right-hander Phil Hughes in their Grapefruit League opener on Wednesday against the Red Sox at JetBlue Park, manager Paul Molitor announced Sunday.
Fellow right-hander Trevor May -- who will be stretched out as a starter, but is also a bullpen candidate -- is set to piggyback Hughes on Wednesday. Right-hander Tyler Duffey will get the nod Thursday night in the home opener at Hammond Stadium, followed by right-hander Ricky Nolasco.
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Left-hander Tommy Milone starts Friday against the Pirates in Bradenton, while right-hander Ervin Santana is set to take the mound on Saturday against the Orioles at Hammond Stadium. Top prospect Jose Berrios is also slated to see action Saturday. Finally, right-hander Kyle Gibson will start on Sunday against the Rays in Port Charlotte.
It's still early, and the rotation can be adjusted, but if the Twins keep the same order, it would line Santana up for Opening Day against the Orioles on April 4 and Gibson for the home opener against the White Sox at Target Field on April 11.
Around the horn
• The Twins held their second day of full-squad workouts with a second day of live batting practice. Notable matchups included Fernando Abad against Joe Mauer, Kurt Suzuki and Trevor Plouffe; Ryan O'Rourke against Byron Buxton, Miguel Sano and Eddie Rosario; and Ryan Pressly and Taylor Rogers facing Byung Ho Park. Lefty reliever Mason Melotakis was one of the bright spots, as he's coming off Tommy John surgery but showed impressive velocity while pitching in front of Molitor.

"It's good to put eyes on people," Molitor said. "I thought Melotakis can get your attention rather quickly, mixing pitches and that fastball."
• Reliever Casey Fien was back in camp on Sunday after missing Saturday's workout due to the birth of his son, Shane Maddux Fien, who was born in Fort Myers early Saturday. Fien is scheduled to throw again on Monday.
• As part of Major League Baseball's new requirement, the Twins hired a full-time Spanish interpreter, as Carlos Font officially joined the organization. Font, 22, is a Puerto Rico native, but lived in Oklahoma City the last eight years, interning with the NBA's Oklahoma City Thunder and the Triple-A Oklahoma City Dodgers.