Orioles Roster & Staff
Orioles
| Date | Transaction |
| 06/25/22 | Baltimore Orioles optioned RHP Marcos Diplan to Norfolk Tides. |
| 06/25/22 | Baltimore Orioles recalled RHP Spenser Watkins from Norfolk Tides. |
| 06/25/22 | Baltimore Orioles recalled SS Jonathan Arauz from Norfolk Tides. |
| 06/25/22 | Baltimore Orioles optioned 3B Rylan Bannon to Norfolk Tides. |
| 06/24/22 | Baltimore Orioles placed RHP Kyle Bradish on the 15-day injured list retroactive to June 21, 2022. Right shoulder inflammation. |
| 06/24/22 | Baltimore Orioles recalled RHP Marcos Diplan from Norfolk Tides. |
| 06/23/22 | Baltimore Orioles traded 2B Patrick Dorrian to Milwaukee Brewers for cash. |
| 06/22/22 | Baltimore Orioles sent LHP Zac Lowther outright to Norfolk Tides. |
| 06/21/22 | Baltimore Orioles recalled 3B Rylan Bannon from Norfolk Tides. |
| 06/20/22 | Baltimore Orioles optioned RHP Mike Baumann to Norfolk Tides. |
| 06/18/22 | Baltimore Orioles activated RHP Joey Krehbiel from the 15-day injured list. |
| 06/18/22 | Baltimore Orioles optioned RHP Logan Gillaspie to Norfolk Tides. |
| 06/17/22 | Baltimore Orioles activated LHP Keegan Akin from the restricted list. |
| 06/17/22 | Baltimore Orioles activated RF Anthony Santander from the restricted list. |
| 06/17/22 | RHP Rico Garcia returned to Norfolk Tides from Baltimore Orioles. |
| 06/17/22 | CF Kyle Stowers returned to Norfolk Tides from Baltimore Orioles. |
| 06/16/22 | Baltimore Orioles optioned LHP Bruce Zimmermann to Norfolk Tides. |
| 06/16/22 | Baltimore Orioles recalled RHP Mike Baumann from Norfolk Tides. |
| 06/15/22 | Baltimore Orioles designated LHP Zac Lowther for assignment. |
| 06/15/22 | Baltimore Orioles optioned SS Jonathan Arauz to Norfolk Tides. |
| 06/15/22 | Baltimore Orioles claimed SS Jonathan Arauz off waivers from Boston Red Sox. |
| 06/13/22 | Baltimore Orioles placed RF Anthony Santander on the restricted list. |
| 06/13/22 | Baltimore Orioles placed LHP Keegan Akin on the restricted list. |
| 06/13/22 | Baltimore Orioles signed free agent RHP Eddy Alberto to a minor league contract. |
| 06/13/22 | Baltimore Orioles selected the contract of CF Kyle Stowers from Norfolk Tides. |
| 06/13/22 | Baltimore Orioles selected the contract of RHP Rico Garcia from Norfolk Tides. |
| 06/12/22 | Baltimore Orioles released SS Chris Owings. |
| 06/11/22 | Baltimore Orioles signed free agent SS Chris Givin to a minor league contract. |
| 06/11/22 | Baltimore Orioles selected the contract of SS Richie Martin and from Norfolk Tides. |
| 06/10/22 | Baltimore Orioles placed 2B Ramon Urias on the 10-day injured list. Left oblique strain. |
| 06/10/22 | Baltimore Orioles sent RHP Cody Sedlock outright to Norfolk Tides. |
| 06/08/22 | Baltimore Orioles activated RHP Austin Voth. |
| 06/08/22 | Baltimore Orioles designated SS Chris Owings for assignment. |
| 06/08/22 | Baltimore Orioles optioned RHP Spenser Watkins to Norfolk Tides. |
| 06/07/22 | Baltimore Orioles activated SS Chris Owings from the bereavement list. |
| 06/07/22 | Baltimore Orioles signed free agent RHP Cesar Espinal to a minor league contract. |
| 06/07/22 | Baltimore Orioles designated RHP Cody Sedlock for assignment. |
| 06/07/22 | Baltimore Orioles claimed RHP Austin Voth off waivers from Washington Nationals. |
| 06/06/22 | Baltimore Orioles optioned RHP Marcos Diplan to Norfolk Tides. |
| 06/06/22 | Baltimore Orioles optioned RHP Marcos Diplan to Norfolk Tides. |
| 06/05/22 | Baltimore Orioles activated RHP Dean Kremer. |
| 06/05/22 | Baltimore Orioles optioned RHP Denyi Reyes to Norfolk Tides. |
| 06/03/22 | Baltimore Orioles placed RHP Joey Krehbiel on the 15-day injured list. Right shoulder inflammation. |
| 06/03/22 | Baltimore Orioles released CF Jahmai Jones. |
| 06/03/22 | Baltimore Orioles placed SS Chris Owings on the bereavement list. |
| 06/03/22 | Baltimore Orioles recalled 3B Tyler Nevin and from Norfolk Tides. |
| 06/03/22 | Baltimore Orioles recalled LHP Nick Vespi from Norfolk Tides. |
| 06/02/22 | Baltimore Orioles signed free agent RHP Juan Pena to a minor league contract. |
| 06/02/22 | Baltimore Orioles signed free agent RHP Ronal Herrera to a minor league contract. |
| 06/01/22 | RHP Yaqui Rivera assigned to Baltimore Orioles. |
| 06/01/22 | Baltimore Orioles signed free agent RHP Elias Moscoso to a minor league contract. |
| 06/01/22 | Baltimore Orioles recalled RHP Denyi Reyes from Norfolk Tides. |
| 06/01/22 | Baltimore Orioles optioned LHP Zac Lowther to Norfolk Tides. |