After White Sox starter Derek Holland retired the first seven Cubs hitters in order, the southpaw walked eight-hitter Tommy La Stella and nine-hitter Jon Jay. Schwarber followed with a mammoth blast to right on a 1-1 pitch.
Holland returned for a fifth inning but didn't retire a hitter. La Stella singled, Jay walked, Schwarber singled home a run and Bryant singled home two more. The runners moved up to second and third on Schwarber's single to right when Avisail Garcia overthrew the cutoff man.
The White Sox No. 3 overall prospect Michael Kopech entered in the sixth inning was dominant for two frames, striking out five and allowing just one hit during his first relief appearance of the spring.
Duane Underwood Jr. started for the Cubs and threw one scoreless frame. Rob Zastryzny worked three innings and held the White Sox from scoring on three hits. Peter Bourjos topped the White Sox offense with two hits, while Tyler Saladino tripled off of Koji Uehara and scored on Geovany Soto's single in the second.
White Sox up next:Carson Fulmer takes the mound for the White Sox in a contest against the Dodgers on Saturday at Camelback Ranch, where the White Sox will be the home team. First pitch is scheduled for 3:05 p.m. CT and can be watched live via MLB.TV. Zach Putnam and Jake Petricka are among the relievers scheduled to throw.
Cubs up next: The Cubs will play two on Saturday, sending half the squad to Maryvale to face the Brewers while the other half will play host to Team Japan in an exhibition game at Sloan Park. First pitch for both games is scheduled for 3:05 p.m. CT, and the Brewers game will be broadcast live on MLB.TV. Jake Buchanan will start against the Brewers, and John Lackey will face Japan. In Buchanan's last outing, he took a ball off his right shoulder, and has a nice bruise still but has been able to do his work between starts.