Escobar was diagnosed with a contusion on the back of his hand. X-rays were negative.
Escobar was in obvious pain and knelt to the ground behind the batter's box, where he was met by Angels manager Mike Scioscia and head trainer Adam Nevala. After a brief consultation, Escobar exited the game and was replaced by pinch-runner Cliff Pennington.
The visible frustration was understandable for Escobar, who was activated from the disabled list Friday after missing 11 games with a concussion sustained when hit in the face by a ball after a bunt attempt on Aug. 19.
Escobar entered Saturday's game tied with teammate Mike Trout for third in the American League with a .320 average.