That was the biggest blow on a night when Houston's bullpen let a late lead slip away as Los Angeles won Game 4 of the World Series, 6-2, on Saturday at Minute Maid Park.
This was a game the Dodgers needed to win to avoid falling into a 3-1 hole. To dig out and tie the World Series at two games apiece changes plenty.
No surprise there. From the beginning, this World Series had the look and feel of two evenly matched teams who were going to be exchanging punches for a while.
For the Astros, it's not that they lost a game. It's how they lost it. Manager A.J. Hinch's most reliable postseason reliever, Brad Peacock, was unavailable after pitching 3 2/3 hitless innings in Friday's 5-3 victory.
So Hinch went back to the guys who'd been his core relievers for most of the season. They'd all been solid, if not dominant.
Chris Devenski was a member of the American League All-Star team this season. Will Harris was an All-Star in 2016. Musgrove had a 1.44 ERA after moving to the bullpen in the second half of the season.
Finally, there was the closer, Ken Giles. He, too, was very good for most of the regular season -- 34 saves, a 1.04 WHIP and 83 strikeouts in 62 2/3 innings.
That was then. Giles, Devenski and Musgrove have been hit hard during the postseason, forcing Hinch to use three starters -- Peacock, Justin Verlander and Lance McCullers Jr. -- out of the bullpen at times.
Hinch said Houston probably can't win this World Series if he can't find some favorable matchups for Devenski, Giles and Musgrove.
Around the clubhouse, Giles' teammates said they had his back.
"I love those guys," outfielder George Springer said. "I love all these guys in there. This game's hard. They're not out there trying to fail. I hope skip keeps giving 'em the ball. I have the utmost confidence in them, and I'm glad they're on my team."
Relievers are almost never noticed until they don't do their jobs. Then every mistake becomes magnified, and they become the loneliest men on the planet. That's why doing what they do requires an ability to turn the page on a bad day.
"So, clearly, he's trying to push through the adversity that he's had," Hinch said of Giles, who has allowed at least one run in six of his seven postseason appearances. "But to be a back-end reliever, you've got to live on that edge of not carrying too long of a memory, because of the things that can happen at the back of the game.
"But you have the ball in your hands at the most critical times, because you have the best stuff. He can get outs, and he'll continue to get outs, but it's been tough on him."
Given that Harris and Devenski had scoreless appearances on Saturday, they could figure prominently on Sunday if Game 5 starter Dallas Keuchel turns a lead over to the bullpen.
In the end, though, the Astros probably can't win this World Series without Giles and Musgrove getting some important outs.
Hinch won't commit to specific roles for anyone, saying he'll look for the best matchups to put his guys in position to succeed.
"Obviously, it builds in the postseason, because there's so much attention on these outs," Hinch said. "And when you're a back-end reliever, oftentimes -- unless you're extraordinarily dominant -- you're only talked about when you suffer, when you struggle."