CHICAGO -- CC Sabathia is going to win his 250th Major League game very soon, and when he does, it’s going to be a special moment.

Unfortunately for him and the Yankees, the milestone eluded both for the third time in Friday night’s 10-2 loss to the White Sox at Guaranteed Rate Field.

• Box score

Sabathia came into Friday’s outing with a solid handle of the White Sox during his career going 19-7 with a 3.67 ERA in 38 starts against Chicago, but his historically solid track record did him no favors this time around. Much of that was due to not getting his cutter where he wanted it to go.

“It just wasn’t there,” Sabathia said. “It wasn’t moving a lot.”

The White Sox immediately ambushed Sabathia, sending nine men to the plate in the first inning and tagging him for four runs. Three runs came via Sox rookie sensation Eloy Jimenez, whose home run in the bottom of the first sent New York to a quick 4-1 deficit. It was his first of two three-run blasts in the game.

The Yankees’ southpaw wasn’t able to use his primary pitch effectively in his 4 2/3 innings of work. He threw 33 cutters in the game with the White Sox putting nine of them in play, including one that was center-cut on the Jimenez homer.

Sabathia admitted following Friday’s loss that he’s fighting the feeling on his signature pitch and looking to re-establish what has made him so successful over the years.

“My grip feels off. Everything about it feels off,” Sabathia said. “I’ve had times like this where the feeling’s been off, but two games like this, this has been the longest stretch. We’re going to have to figure something out between today and Wednesday to get it back where it needs to be.”

“He was struggling with his cutter. Just from the velocity, shape of the pitch and getting it where he wanted to,” manager Aaron Boone said.

Sabathia’s road woes continue to plague him, as he moved to 1-3 with a 6.30 ERA in six starts away from Yankee Stadium this season.

It also shines the light on a Yankees rotation that has failed to record a quality start in seven straight games. With a four-man rotation trying to stay afloat, Yankees starting pitchers know 4 2/3 innings like they got tonight aren’t going to get it done.

“It’s tough, especially with us not pitching well right now,” Sabathia said. “You wanna go out and help the team. I just wasn’t able to do that tonight.

“It’s just a long season. We’ve had a bad 10 days, but this team is very capable of doing what they did before that.”

Bats go silent
The American League Cy Young front-runner continued to show why he’s been one of the best pitchers in the game. White Sox starter Lucas Giolito silenced the Yankees’ offense after Luke Voit's solo homer in the first inning.

Giolito tossed six-plus innings, allowing just one earned run for his Major League-leading 10th victory of the season.

While Voit’s homer made it 17 consecutive games in which the Yankees have homered, they have also fanned 20 times in the last two games vs. Sox pitching.

“That’s a hot pitcher right now. The guy’s been throwing the ball really well. He settled in and showed us why he’s been so tough,” Boone said. “The ability to pitch with his fastball, but that changeup in any count that he’s able to throw even if he’s behind is an equalizer for him. He made it tough on us.”