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The players listed below could provide difference-making stats for DraftKings participants on Friday.
Anthony Rizzo: The first baseman has used his combination of power and patience to post a lifetime .268/.366/.494 slash line against right-handers. Rizzo could post a notable DraftKings total when he faces righty Bud Norris (5.28 ERA, 1.61 WHIP in 2016) and a Braves bullpen that ranks 26th in baseball with a 4.34 ERA.
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Jason Heyward: The outfielder has long fared best vs. right-handers, against whom he has logged a lifetime .823 OPS (.664 vs. lefties). Heyward has the plate skills to thrive against the righty Norris (career 4.48 ERA, 1.41 WHIP) and the speed to swipe a base against catchers A.J. Pierzynski or Tyler Flowers, who have combined to throw out nine of 53 would-be basestealers in 2016.
Video: CHC@PHI: Heyward connects for 100th career homer
David Ortiz: Much of the slugger's impressive career track record can be traced to his .294/.397/.584 slash line against right-handers. Hitting .338 with 16 homers and 55 RBIs across 195 at-bats this season, Ortiz could stay hot when he faces righty Tyler Duffey (4.79 ERA, 1.45 WHIP in 2016) and a Twins relief corps that ranks 25th in the Majors with a 4.26 ERA.
Travis Shaw: The third baseman could improve on his lifetime .272/.341/.465 slash line against right-handers when he tangles with the right-handed Duffey (career 1.37 WHIP). Also working in Shaw's favor: Minnesota ranks last in the Majors with a .664 defensive efficiency ratio.
Mookie Betts: With 14 homers, 11 steals, 45 RBIs and 55 runs across 279 plate appearances, the outfielder has been one of the most productive players in baseball this season. Betts has the plate skills to thrive against Duffey and the speed to swipe a base against catcher Kurt Suzuki, who sometimes struggles to thwart would-be base stealers.
Paul Goldschmidt: With a lifetime .327/.430/.593 slash line against left-handers, Goldschmidt has proven to wield a potent bat during those matchups. The first baseman could go deep or drive in multiple runs when he bats at his hitter-friendly home park against Marlins southpaw Justin Nicolino (career 4.15 ERA, 1.30 WHIP).
DJ LeMahieu: With balanced career splits and a lifetime .316/.367/.425 slash line at his hitter-friendly home park, the second baseman will be poised to produce when he hits at home against Andrew Cashner (4.78 ERA, 1.46 WHIP in 2016) and a Padres bullpen that ranks 28th in baseball with a 4.75 ERA.
Brian McCann: With 34 homers since the outset of 2015, the catcher is arguably the most powerful player at his premium position. The left-handed-hitting McCann is a prime candidate to go deep when he faces Tigers right-hander Mike Pelfrey (career 4.53 ERA, 1.49 WHIP) at Yankee Stadium, which is especially power-inducing for lefty batters.
Didi Gregorius: The shortstop has posted notable career splits, with a .712 OPS against right-handers that exceeds his .595 mark vs. lefties. Gregorius could provide production at a premium position when he bats at his hitter-friendly home park against the righty Pelfrey (4.76 ERA, 1.72 WHIP in 2016) and a Tigers bullpen that ranks 27th in baseball with a 4.37 ERA.
Francisco Lindor: With a lifetime .332/.377/.507 slash line against left-handers, the second-year shortstop is emerging as one of the best in baseball during those matchups. Hitting out of a premium lineup spot, Lindor could reach base often or drive in multiple runs at the expense of Angels southpaw Hector Santiago (5.07 ERA, 1.31 WHIP in 2016).
Nelson Cruz: As a big leaguer, Cruz has posted a .925 OPS against left-handers that exceeds his .821 mark vs. righties. The only player to go deep at least 40 times in each of the previous two seasons, Cruz will be in position to display his power when he tangles with Rangers southpaw Derek Holland (career 4.29 ERA, 1.32 WHIP, 1.2 HR/9 rate).
Video: CLE@SEA: Cruz mashes his second homer of the night
Chris Iannetta: With a lifetime .865 OPS against left-handers that exceeds his .708 mark vs. righties, the catcher could deliver cost-effective production at a premium position when he faces the left-handed Holland (4.53 ERA, 1.31 WHIP in 2016) and a Rangers relief corps that ranks 29th in the Majors with a 4.86 ERA.
Franklin Gutierrez: Gutierrez has produced pronounced career splits, with an .839 OPS against left-handers that exceeds his .657 mark vs. righties. The outfielder could succeed against Holland, who in his career has allowed right-handed batters such as Gutierrez to post a .775 OPS (.648 OPS allowed to lefty batters).
Clayton Kershaw: With a 1.94 ERA, a 0.81 WHIP and an 11.3 K/9 rate since the outset of 2015, the left-hander has left little doubt that he is the most dominant pitcher in baseball. Kershaw may be worth a notable investment in DraftKings contests when he faces the Giants at pitcher-friendly AT&T Park.
Steven Wright: With a 2.29 ERA and a 1.13 WHIP, the right-hander has been a cost-effective option in many DraftKings contests this season. Wright could continue his breakout campaign when he faces a Twins lineup that ranks 22nd in the Majors with a .710 OPS against righties. He could pick up a win if his supporting cast -- owners of an MLB-leading .835 OPS against right-handers -- has success against Duffey.
Stephen Strasburg: Having produced a 2.85 ERA, a 1.09 WHIP and an 11.4 K/9 rate, the right-hander has been one of the most dominant starters in baseball this season. Strasburg could continue his stellar year when he works at home against a Phillies lineup that ranks 28th in the Majors with a .667 OPS against righties.
Video: WSH@CIN: Strasburg records 1,000th MLB strikeout
Jason Hammel: The right-hander will be in prime position to improve on his impressive stats this year (2.14 ERA, 1.08 WHIP) when he works at pitcher-friendly Turner Field against a Braves lineup that ranks last in the Majors in OPS vs. righties (.627) and total home runs (23). Also working in Hammel's favor: Chicago leads the Majors with a .740 defensive efficiency ratio.
All statistics are accurate through the completion of Wednesday's games.
Fred Zinkie is the lead fantasy baseball writer for MLB.com. Follow him on Twitter at @FredZinkieMLB