Van Slyke has been playing with discomfort since originally spraining the wrist on a slide last year.
The outfielder saw limited action last September because of it and was left off the postseason roster. He said doctors will remove cysts and scar tissue in a clean-up procedure so he can regain range of motion without pain.
"It feels like a sprained ankle that never really goes away," Van Slyke said. "I feel it swinging and throwing."
He expects to be in a cast for a week and then begin rehab so he will be completely healed before Spring Training begins.
Injuries to Van Slyke and Trayce Thompson have provided unexpected playing time and pinch-hit at-bats for Rob Segedin, who possesses similar right-handed power.
Ken Gurnick has covered the Dodgers since 1989, and for MLB.com since 2001.