While running around first after that single to center, Davidson apparently suffered a fracture in his right foot. He was being evaluated by the team and didn't speak postgame, but he will go on the disabled list prior to Friday's series opener in Houston, with a corresponding move to follow.
This latest injury to the International League All-Star who came from Triple-A Charlotte to the White Sox prior to Thursday's contest adds to the list of strange mishaps this season for Chicago's callups. Catcher Kevan Smith was scheduled to start on April 25 against the Blue Jays, but he hurt his back during pregame stretches.
Jason Coats, who pinch-hit for Davidson in the sixth on Thursday, collided with center fielder J.B. Shuck during Coats' debut in Detroit on June 4 and required stitches in his lip after leaving the game.
"We're hot that way. I think they're afraid to come up," said White Sox manager Robin Ventura of the latest rookie injury. "It's odd. I think Smitty was the oddest of all of them.
"You could see it from Matty. He said he did it going around first, but you could see it when he went from second to third. I know he's not a good runner, but it was remarkably poor at that point for him to keep going. It's just crazy."
Hitting home runs became a consistent trait for Davidson, whom the White Sox acquired from Arizona for closer Addison Reed on Dec. 16, 2013, even when he struggled mightily for Charlotte during the 2014-15 seasons. He cleared the fences a combined 43 times despite posting 355 strikeouts and hitting around .200 in both years.
But the 25-year-old looked like a different player this past Spring Training, making it a tough decision for the White Sox to send him back to Charlotte. Davidson continued that success during the season, batting .268 with 10 homers and 46 RBIs.
Over his last six games for the Knights, Davidson finished 10-for-21 with two homers and nine RBIs.
"This was my goal, to be here. It's been a long ride, but I'm glad to be here," said Davidson during a pregame talk with reporters. "I made a lot of adjustments and I have keys I go back to when I struggle. If I'm not feeling well, I just kind of do the same thing every single day.
"Before, I just kind of hit and didn't really know what I was doing, I guess. It was just kind of athletic ability doing that. I had to learn and understand my body. Now I always go back to the same routine, and it's helped me this year."
Davidson became the 15th different player promoted from Charlotte this season.