"The one thing I'll rely on is how he feels, and then what he tells me, what the medical people tell him," Rangers manager Jeff Banister said of the 35-year-old slugger. "A guy with experience like that, you trust what they tell you.
"Typically, it doesn't take those guys [veterans] a lot of time, at-bats. As long as he's healthy and feels good with his timing, the body feels good, it's not out of the realm of possibility to see him this weekend."
After an off-day Thursday, the Rangers are at Globe Life Park on Friday to open a three-game series with Seattle.
Napoli was placed on the 10-day disabled list retroactive to June 4.
In his third stint with Texas, Napoli is batting .192 with 11 home runs and 25 RBIs in 51 games.
Banister also announced that left-hander Cole Hamels, who has been on the DL retroactive to April 30 with a right oblique strain, could make a rehab start on Friday.
Richard Dean is a contributor to MLB.com based in Houston and covered the Rangers on Wednesday.