In the second inning, Harrison was hit in the left foot by a 90 mph sinker from Chicago pitcher Jon Lester. He stayed in the game initially and played the field in the top of the third, but Joyce pinch-hit for Harrison in the bottom of the third. Sean Rodriguez moved from right field to second base in the top of the fourth, and Joyce went to right field.
Then in the sixth, Adam Frazier took over for Joyce in right field.
Hurdle said the injury to Harrison had been checked out and didn't look serious.
"I believe the tests are done. Everything's fine. He's got foot discomfort," Hurdle said.
Hurdle couldn't pinpoint when Joyce had tweaked something, though Joyce was walking around the clubhouse postgame.
Sarah K. Spencer is a reporter for MLB.com based in Pittsburgh.
This story was not subject to the approval of Major League Baseball or its clubs.