A week and a half after completing a blockbuster trade that sent left-handed starter Jose Quintana from the White Sox to the Cubs for prospects, the crosstown rivals open up a two-game set at Wrigley Field streaming live on MLB.TV.
Quintana, dealt for outfielder Eloy Jimenez (No. 8 overall prospect, per MLBPipeline.com), pitcher Dylan Cease (No. 62 overall), first baseman Matt Rose and middle infielder Bryant Flete, will not get a chance to pitch against his former club. A number of other enticing storylines remain, however, including top prospect Yoan Moncada's introduction to the Cubs-White Sox rivalry and the return of Kyle Hendricks to Joe Maddon's rotation.
The clubs that represent the South Side and North Side of Chicago have met 108 times since Interleague Play began in 1997, with the White Sox leading the series overall, 57-51.
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Here's what to watch among 13 games on MLB.TV throughout the day (all times in ET):
Chi-Town rivalry: CWS@CHC, 2:20 p.m.
Hendricks is slated to take the mound after missing over a month and a half with right hand tendinitis. He'll face off with White Sox righty Miguel Gonzalez in the opening game of a four-game home-and-home set.
Hendricks will look to turn his season around after going 4-3 with a 4.09 ERA in his first 11 starts finishing 16-8 with a 2.13 ERA in 30 starts last season.
Gonzalez will attempt to build on his previous outing, in which he allowed just one run over six innings in a tough-luck loss to the Dodgers. Moncada has managed just one hit in 13 at-bats since being called up earlier this week.

Push for postseason: COL@STL, 8:08 p.m.
Two teams looking to gain ground in the NL postseason race will meet in St. Louis when the Rockies and Cardinals begin a three-game set at Busch Stadium.
Rockies rookie right-hander Antonio Senzatela will get the ball trying to build on his victory over the Padres, while veteran righty Mike Leake will attempt to bounce back from a loss to the Mets.

Battle in Seattle: BOS@SEA, 10:10 p.m.
Solid southpaws Eduardo Rodriguez and James Paxton will square off at Safeco Field when the Red Sox head to Seattle to take on the Mariners. 
Rodriguez gave up three runs over 5 1/3 frames versus the Blue Jays in his first start of the second half, while Paxton has rattled off four straight wins to pair with a 2.05 ERA in July.

Colon's final start?: MIN@LAD, 10:10 p.m.
Retirement rumors have swirled around 44-year-old Bartolo Colon after he allowed four earned runs in four innings in his first start with the Twins, but the veteran right-hander insists he's just focused on pitching for Minnesota.
Seemingly taking things start by start in the final stages of his impressive 20-year career, Colon (2-9, 8.19) will take the ball against Hyun-Jin Ryu (3-6, 4.21) and the Dodgers.
Ryu is slated to be activated from the disabled list to make this start after missing three weeks with a bruised left foot.