Myers landed on the 10-day disabled list on April 4 after exiting a game two days earlier because of nerve irritation in his right arm. Myers most recently completed a three-game rehab assignment with Class A Advanced Lake Elsinore, where he clubbed two home runs.
Myers is starting in right field and hitting second as the Padres open a three-game series with the D-backs on Friday.
"We missed his athleticism as much as anything, just the ability to change games on the basepaths," Padres manager Andy Green said. "Obviously, we missed his power. Just putting him back in the middle of the order extends our lineup quite a bit and it's going to be good to have him in there."
Green said Myers will get a day off somewhere within the next six, but he isn't sure when.
Myers was also battling a balky back, along with the nerve irritation.
"It was just one of those things where I needed some rest," he said. "You could do all the treatment you wanted, but at the end of the day, it just needed rest."
He's had plenty of that over the past two weeks and said he feels good now. He didn't rush back, either, as Green said Myers asked for a third game on his rehab stint.
Myers moved back to the outfield from first base this season because of the Eric Hosmer signing during the offseason. Though Myers hadn't been a regular outfielder for a couple years, he said the position change didn't strain him further physically.
"I think this is just a freak thing," he said. "It was just one of those things that kind of happened out of nowhere, so I don't really think it had anything to do with my position. Just more of a freak thing."
Perdomo sent down to further develop
Green made something clear when speaking about sending right-hander Luis Perdomo down to Triple-A El Paso.
"It wasn't, 'Hey, we'll see you in two weeks.' It wasn't 'see you in two years,' either," he said. "It's on him to go down, execute, pitch well and when the time comes, we'll bring you back."
Perdomo holds a career 5.30 ERA over 53 big league starts.
In four starts this year, he has an 8.36 ERA. One of the starts was brief, because he was ejected, and later suspended for throwing behind the Rockies' Nolan Arenado.
Prior to being sent down, Perdomo allowed nine runs -- seven earned -- in just three innings during a 13-4 loss to the Dodgers.
"It was just time," Green said of sending down Perdomo. "I don't mean that in a bad sense. Luis has done everything we've asked as far as giving effort and attention to detail. He's pushing himself incredibly hard.
"He's skipped a lot of steps in the development cycle, and we hoped we wouldn't have to go back and revisit those steps. It just became apparent to us over the early season, and him having those steps now is going to be productive for him."
Most importantly, Green said, Perdomo needs to become more consistent. He's shown flashes, but has also had his issues.
Yates, who has become the Padres' primary setup man, had pitched 3 2/3 scoreless innings with five strikeouts before his DL stint. Green said it might have been nice to send him off for a rehab outing, but ultimately decided not to.
"We needed that fresh arm, a guy that can get big outs for us in big situations, so we're glad to have him back as well," Green said.
Green said Yates "checked all the boxes" in live batting practice earlier this week. He threw strikes and his splitter looked good.
Asked about the type of situation Yates would be used for on Friday in Arizona, Green said:
"If it calls for him, we'll use him. ... We won't hesitate."
Green said center fielder Manuel Margot, who suffered bruised ribs in a series at Colorado last week, took six at-bats at the Padres' minor league complex on Friday. It's possible that he'll return on Saturday.
Margot feels fine, according to Green, but it's just a matter of how many at-bats he needs to feel ready.
"Lots of guys dig back in the box after being hit in the ribs like that, and it's hard for them to put that out of their mind and start competing again," Green said. "Doesn't seem like there's any of that trepidation, and we're glad he feels that way. We just want to make sure his timing is as close to game-like as possible."
Justin Toscano is an associate reporter for MLB.com.