Manager Rocco Baldelli was unsure when the issue first flared up, but noted that Simmons has dealt with ankle problems in the past and reported feeling an issue in the area following a slide in Tuesday night's loss to the White Sox. Simmons missed a week and a half in June 2018 with a right ankle sprain.
Simmons took a bases-loaded walk in the top of the sixth and moved to third on Luis Arraez's two-run single against White Sox reliever Even Marshall before exiting the game between half-innings.
"He was pretty uncomfortable moving around," Baldelli said. "He didn't look comfortable at shortstop or running the bases or even swinging the bat. ... He completely understood what we were doing and why we were doing it."
Simmons played in Wednesday's game with the ankle taped up, but the pain got to a point where the shortstop was "unplayable," Baldelli said. The Twins expect to have a further update on Thursday.
If the issue is enough to sideline Simmons, Minnesota would likely need to recall Nick Gordon from Triple-A St. Paul, as Jorge Polanco would then be the only remaining player on the active roster capable of playing shortstop. Gordon walked, singled and stole two bases in his MLB debut last Thursday, and he can play both second base and shortstop.
Simmons is hitting .241/.341/.329 with a homer and four doubles this season.