CHICAGO -- The weather was overcast and dreary Sunday at Guaranteed Rate Field. It perfectly matched the Angels’ performance in the finale of the three-game series against the White Sox.

The Angels struggled to get anything going at the plate or on the mound and suffered a 5-1 loss after winning the first two games.

• Box score

Chicago starter Dylan Cease couldn’t get through the fourth inning, but he managed to give up just one run on four hits. The Angels left the bases loaded in each of the first two innings and didn’t capitalize on five walks by the rookie right-hander.

“The first two innings, he was able to wiggle out of it with just giving up one run, and then he settled down a little in the last two he threw,” Angels manager Brad Ausmus said. “We had our chances to kind of turn the tide against him.

“We had a good approach. We forced him to get in the strike zone, we got some walks and mixed in some hits, but we just couldn’t get that big hit to open it up.”

Still, things started relatively well for the Angels. Shohei Ohtani continued his hot hitting with an RBI single in the first inning for a 1-0 lead.

To that point, Ohtani was 6-for-10 in the series, but he struck out in each of his next three at-bats against Cease and left-handers Josh Osich (2-0) and Aaron Bummer.

Ausmus, though, isn’t concerned that Ohtani's hot streak is over.

“They’ve got some pretty good left-handed pitchers,” the manager said. “Aaron Bummer has some of the best stuff from the left side I’ve seen all year, so I just don’t think it was Shohei who struggled. Everybody struggled, including right-handed batters.”

Whatever momentum the Angels had at the end of the top of the first was short-lived, as opener Noé Ramirez quickly gave the run back in the bottom of the inning and recorded only two outs.

Right-hander Jaime Barria (4-8) came on to get the final out of the first. Barria, who was listed as the starter prior to the game, allowed two runs on four hits in 4 1/3 innings. He gave up solo home runs to Jose Abreu and Danny Mendick.

Barria lost for the fifth straight time. He is 1-3 with a 12.68 ERA in four games when following an opener this season.

“I feel good about the outing,” he said through a translator. “I stuck to my normal routine. Overall, I feel pretty good about it.”