PHOENIX -- The Giants placed No. 2 starter Anthony DeSclafani on the 10-day injured list on Wednesday with right shoulder fatigue, but manager Gabe Kapler is optimistic that the 31-year-old veteran won’t be out for long.

Kapler said the expectation is that DeSclafani will miss only one start before rejoining the rotation, but the Giants likely want to be mindful of his workload after he pitched only 33 2/3 innings during an injury-marred, pandemic-shortened 2020 campaign.

DeSclafani gave up five runs (four earned) over 4 1/3 innings in the Giants’ 11-8 win over the D-backs on Monday and has now logged a 6.63 ERA over his last four outings, bumping his ERA to 3.28 on the season. The IL placement is retroactive to Tuesday, meaning DeSclafani will be eligible to return on Aug. 13.

“As you guys saw, he’s still got good arm strength and arm speed,” Kapler said. “Good velo. I think it’s just an opportunity for him to be at his healthiest and strongest down the stretch. Right now, the expectation is that he’ll miss one start. These things can take some twists and turns, but that’s the expectation right now. It felt like it was the right time to get him as healthy and strong as possible.”

Kapler said Aaron Sanchez, who worked around four walks to post three scoreless innings in relief on Tuesday, will be a candidate to make a spot start this weekend at Milwaukee, though the Giants could also call up Tyler Beede or Sammy Long from Triple-A Sacramento.

In a pair of corresponding moves, the Giants activated infielder Tommy La Stella off the 60-day IL and designated left-hander Conner Menez for assignment. La Stella started at third base against D-backs right-hander Zac Gallen on Wednesday after missing three months with a hamstring strain and a thumb fracture. La Stella’s return allowed the Giants to give his former Cubs teammate, Kris Bryant, a scheduled day off.

Less than an hour before first pitch, the Giants also scratched Mike Yastrzemski from the starting lineup with a tight right hamstring. Thairo Estrada started in right field in place of Yastrzemski and batted eighth against Gallen.

Luciano promoted

Shortstop Marco Luciano, who is ranked the Giants’ No. 1 prospect by MLB Pipeline, was promoted from Low-A San Jose to High-A Eugene on Wednesday. Luciano, 19, batted .278 with a .930 OPS while leading Low-A West with 18 home runs over 70 games this season.