TORONTO -- Saturday was a tough day at the office for Blue Jays pitchers.

Edwin Jackson took the mound to start the second game of the three-game Interleague series against the Padres at Rogers Centre, and the 35-year-old right-hander struggled to keep the ball in the yard.

Though Jackson wasn’t the only one -- the Blue Jays helped the Padres to a new franchise record of seven home runs in a single game in an eventual 19-4 loss for the home team -- he shouldered the blame for what happened throughout.

• Box score

“Every time we made a mistake, they made us pay,” Jackson said. “And that’s what teams do when they’re hot and when they’re hitting. You make mistakes, they don’t miss them too often, and today they didn’t miss many mistakes.

“But I feel like that game is on me, myself as a starter, I have to do a better job of controlling the game and going deeper in the game before it even has to get to the ‘pen that early.”

Jackson was hit early and often by the visitors, allowing seven runs on seven hits with one walk and two strikeouts over four innings. Three Padres hit homers off Jackson, with Wil Myers and Ian Kinsler going back to back in the second inning, and Austin Hedges adding his first career grand slam in the fourth. The last time the Blue Jays’ righty allowed seven runs in a game was Sept. 15, 2017.

“It’s [happened] a couple times,” Jackson said. “Today was just one of those days where I didn’t really like the focus, I didn’t like the execution and it showed on the field. I feel like that game got out of hand before it even got to the bullpen. I have to do a better job of making pitches and going deeper into ballgames.”

Things went from bad to worse for Toronto when Jackson exited the game. Thomas Pannone came on in relief in the fifth, and after allowing three consecutive one-out singles to load the bases, he allowed all three of those hitters to score on back-to-back walks, followed by a bases-loaded HBP.

Derek Law deepened the hole when he allowed a two-run home run to Hunter Renfroe in the sixth, Zac Rosscup allowed two runs (one earned) in his Blue Jays debut in the seventh, and Sam Gaviglio allowed three home runs in a five-run eighth that saw Eric Hosmer go yard, as well as Renfroe and Myers completing their multi-homer games.

“It’s just one game,” Blue Jays manager Charlie Montoyo said.

“In this game you have to have a short-term memory,” Jackson said. “You make your adjustments from game to game, you can’t let things linger with you. We play too many games to let one game linger with you the rest of the season.

“It’s a game of adjustments at the end of the day and it’s about how quick can we make adjustments and how quick can we have a short-term memory and not hang onto bad thoughts, and continue to move on and continue to progress instead of regress.”

Toronto sent catcher Luke Maile to the mound for the top of the ninth to spare the bullpen any further damage and to keep Joe Biagini (who came in for the last out of the eighth) fresh for Sunday’s finale if needed. The righty induced two called strikeouts and a popup to work around a hit and a hit batsman.

Saturday’s start was Jackson’s third with the Blue Jays, the right-hander coming off a five-inning outing against the Red Sox on Monday, in which he allowed six runs (five earned) on seven hits, with one walk and four strikeouts. At the time, those six runs were the most he’d allowed since Sept. 22, 2017, against the Mets.

“I just need to make adjustments,” Jackson said. “I’ll just go back and watch a couple videos, look at a couple things that I could have done differently. It’s just a matter of focus I feel like. I didn’t like the focus today and I didn’t like the execution and I feel like there were a couple pitches where obviously I could have made better pitches and I feel like it changed the outcome of the game.”

Added Montoyo, “He knows what he needs to do. And he’s got the stuff to get people out, so hopefully he’ll get it. I think he’ll get it. Just a tough outing today.”

The Blue Jays amassed three runs on just two hits against Port Hope, Ontario, native Cal Quantrill. Lourdes Gurriel Jr. hit his second home run in as many games since making his return from Triple-A Buffalo with a solo shot in the second inning. Justin Smoak chipped in with his ninth home run of the season, a two-run knock in the fourth.