BOSTON -- It has now been one year and 12 days since the Red Sox have beaten the Yankees in MLB’s most storied rivalry.

Making that dreary fact more agonizing is that Boston was just an out away from reversing that misfortune on Friday night, only to have Gary Sánchez pummel a game-tying homer off Matt Barnes in the top of the ninth.

And in the 12th, it was DJ LeMahieu who at last put the Yankees ahead for good with an RBI double down the line in right to hand the Red Sox a 6-5 loss in a game that took four hours and 55 minutes.

• Box score

How did this night stack up among the most frustrating defeats for a team that is now 19-33 with eight games left?

“It was definitely one of them,” said Red Sox manager Ron Roenicke. “Actually played great defense. We made some outstanding plays throughout that game. Martín Pérez, outstanding job pitching. Actually we threw the ball well. We had plenty of opportunities to win that game offensively. So, tough one to lose.”

In particular, it was tough for J.D. Martinez, who continued his utterly frustrating season with an 0-for-6 night that included four strikeouts. Martinez slipped below the Mendoza Line at .199, and has just five homers and 22 RBIs.

“With a guy that’s been as consistent as he has over the years, to go through this little stretch is, I’m sure, pretty rough for him,” Roenicke said. “You keep thinking he’s going to come out of it, he has some good games, then he doesn’t. Tough night. One of the best hitters in the game and he’s going through this.”

The teams traded runs in the 11th, with the Sox tying it back up on Christian Arroyo’s RBI single through a drawn-in infield.

Martinez had a golden chance to end the game with one swing that inning. Yankees manager Aaron Boone walked Xander Bogaerts to load the bases with one out, but Martinez struck out.

• Verdugo exits with hamstring tightness

The defeat makes the Red Sox 0-11 against the Yankees since Sept. 7, 2019. That includes eight games this season, the first seven of which were played at Yankee Stadium. This is the first time Boston has lost 11 in a row to New York since 1952-53.

“It’s not a good feeling,” Pérez said. “But they played better than us. They’re pitching better than us. We don’t have any excuses. Sometimes you play hard and you don’t win the game, but that’s baseball. I think we played good tonight, and we couldn’t get the win.”

Fortunately for the Red Sox, it really isn’t about the wins and losses right now. They’ve already been eliminated from postseason contention.

It is more about the evaluations heading into next season. And certain things are crystallizing when it comes to the 2021 Red Sox. For example, Pérez and Arroyo are two players who seem primed to be part of the plans.

Backed by a tremendous effort from the mound by Pérez (6 innings, 3 H, 0 R, 7 K’s) and a big night at the plate from Arroyo (3-for-5, including a three-run homer), the Red Sox were in position to win this one until Barnes caught too much plate with an 0-1 curveball to Sánchez, who clubbed his 10th homer of the season.

Pérez (4-4, 3.88 ERA) has been Boston’s most consistent starter. In fact, he has been the only starter not to miss a turn in the rotation. The Red Sox hold a $6.25 million option on him for next season, which seems like a bargain.

“Great fastball, great location, mixed in the offspeed well, but that’s as good of a fastball as you can have, locating it -- inside most of the time, running it away when he needed to,” Roenicke said. “The cutter was really good. It was a big game for him that we really needed. That was pretty fun to watch him pitch.”

Arroyo -- a former first-round Draft pick of the Giants who has battled injuries and inconsistency throughout his career -- has really come on over the last week, and he is still a year away from being arbitration-eligible.

The position of second base is wide open for the Red Sox, who basically haven’t had the injured Dustin Pedroia for the past three seasons. Arroyo looks like he might be capable of sliding in.

Aside from crushing that three-run homer over everything in left at an exit velocity of 107 mph and a Statcast-projected distance of 418 feet, Arroyo also looked good on defense, starting a pretty double play off the bat of Gio Urshela in the second and turning one swiftly on a nifty feed from Bogaerts to erase Aaron Judge in the sixth.