He tied the game at 1 with the 20th home run of his career.
But in the first inning, Casali's wild throw led to a Padres run. His high toss to first baseman Joey Votto allowed Travis Jankowski to reach safely. Jankowski came around on a stolen base, wild pitch and a sacrifice fly.
Casali also walked and singled, finshing the night 2-for-3.
His role with the Reds will be as Tucker Barnhart's backup.
Jay Paris is a contributor to MLB.com based in San Diego.