Key takeaways: Astros 6, Padres 3

4:45 AM UTC

SAN DIEGO -- For the second time in three days, the Padres got an underwhelming performance from a newly acquired starting pitcher.

took the loss on Friday night, as San Diego dropped the opener of its weekend series against the Astros, 6-3. Here’s some instant reaction from Petco Park:

Five laborious innings for Ray

It’s fair to expect a whole lot more from the Padres’ newest starters in their next turn through the rotation. Ray did not turn in the dud that Casey Mize did on Wednesday in Arizona. But he wasn’t anywhere near his best on Friday night.

Ray walked five Astros and allowed seven hits. He only struck out two. In an odd way, the four runs he allowed were a testament to Ray’s guile. Because he probably could have allowed more.

In defense of Mize and Ray, it’s been an awkward couple of weeks. Both had their schedules thrown completely off. Mize went 11 days without pitching. Ray hadn’t started since he faced the Padres on July 30 at Petco Park while he was still with the Giants. He was a lot sharper that night.

Both looked like they were shaking off some rust. Ray allowed a second-inning homer to Cam Smith -- and that was the only inning in which he wasn’t dealing with major traffic on the basepaths.

Tatis climbs the HR leaderboard

seemed none too pleased with Astros starter Ronel Blanco in the top of the fifth. Blanco appeared to be quick-pitching Tatis, who tried to step out of the box, but wasn’t granted time. A pitch later, Tatis felt Blanco had begun his windup before he was ready.

Nonetheless, the count ran to 3-1 -- and Tatis took all those frustrations out on Blanco’s ensuing slider.

He launched a missile to the second deck of the Western Metal building in left field. After a season-opening drought that lasted more than two months, Tatis is now into double figures, with his 10th home run of the season.

He’s also alone in third place on the Padres’ all-time home run leaderboard with 162, surpassing Adrián González. He’s one shy of Nate Colbert for second all-time (with sitting in first with 217).

Missed opportunities

The Padres certainly had their chances. They put runners on base in every inning from the first through the seventh. But they hit into inning-ending double plays in the second and fourth, and Sung-Mun Song was caught stealing third base for the first out of the third inning.

Trailing by two in the seventh, the Padres loaded the bases for Luis Rengifo. With the tying and go-ahead runs on base, the ballpark reached a crescendo. But Rengifo bounced harmlessly to second against Astros setup man Bryan Abreu.

The Padres wouldn’t seriously threaten after that.