CHICAGO -- Odrisamer Despaigne made his first quality start since 2017 during his White Sox debut Monday night in a 12-1 loss to the Nationals at Guaranteed Rate Field.

But with all due respect to the 32-year-old right-hander, whose contract was purchased from Triple-A Charlotte earlier in the day, Chicago had bigger issues to digest.

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The White Sox lost third baseman Yoán Moncada at the start of the seventh inning, replaced defensively by Jose Rondon. Moncada left the game with upper back tightness and is considered day to day.

Moncada singled with two outs in the sixth inning and didn’t show any true signs of pain as he moved toward second on Jose Abreu’s inning-ending groundout. But television cameras caught Moncada describing his pain to White Sox head athletic trainer Brian Ball and assistant athletic trainer James Kruk on the bench by pointing to the pain in the back area using Welington Castillo to illustrate where.

“It just started my first at-bat. It wasn’t something really serious, but it was progressing. My last at-bat, I felt more discomfort,” Moncada said through interpreter Billy Russo, describing the pain as more in the middle of the back pushing toward the left side. “It is bothering me a little bit. It’s not too serious. I hope to be better tomorrow.”

“He just started feeling it when he was running,” White Sox manager Rick Renteria said. “I don't believe it happened on the swing. I just know he was having a tough time breathing.”

With that sixth-inning single, Moncada extended his hitting streak to 11 games. Aside from that, the White Sox (31-34) didn’t do much more offensively against starter Anibal Sanchez and three Washington relievers, aside from Leury Garcia’s sixth-inning home run. The South Siders’ modest two-game winning streak came to an end with the loss.

Despaigne allowed three runs on seven hits over six innings, striking out two and walking two, while dipping to 0-4 with a 7.50 ERA over his last six starts in the Majors. The right-hander, who is currently starting in place of Dylan Covey, also seemed to employ a later warmup plan before the game began but said it was nothing out of the ordinary.

“Not at all. That’s the way that I do my warmup,” Despaigne said through Russo. “I usually do more stuff in the gym and inside than outside. It wasn’t anything different. That’s my routine.”

“Interesting way of going about it, in terms of prep,” Renteria said. “Really just loosey goosey, did his job. Their guy, again, we weren't able to do a whole lot against him. But as far as Despaigne was concerned, he definitely gave us a chance.”

Jose Ruiz, Josh Osich, Thyago Vieira and Juan Minaya combined to allow nine runs over three innings out of the White Sox bullpen, as Chicago fell to 0-3 on the season against the Nationals. The White Sox hope it was just one long night at the office and that Moncada’s back issue does not become a long-term issue.