Guardians Roster & Staff
Transactions
| Date | Transaction |
| 05/30/22 | Cleveland Guardians traded SS Yu Chang to Pittsburgh Pirates. |
| 05/26/22 | Cleveland Guardians placed RF Franmil Reyes on the 10-day injured list retroactive to May 25, 2022. Right hamstring tightness. |
| 05/26/22 | Cleveland Guardians designated SS Yu Chang for assignment. |
| 05/26/22 | Cleveland Guardians recalled SS Richie Palacios and from Columbus Clippers. |
| 05/26/22 | Cleveland Guardians recalled LHP Konnor Pilkington from Columbus Clippers. |
| 05/26/22 | Cleveland Guardians selected the contract of RF Oscar Gonzalez and from Columbus Clippers. |
| 05/25/22 | Cleveland Guardians placed RHP Aaron Civale on the 15-day injured list retroactive to May 22, 2022. Sore left glute. |
| 05/25/22 | Cleveland Guardians traded RF Daniel Johnson to New York Mets. |
| 05/22/22 | Cleveland Guardians sent RHP Luis Oviedo outright to Columbus Clippers. |
| 05/20/22 | Cleveland Guardians activated 1B Josh Naylor from the 10-day injured list. |
| 05/20/22 | Cleveland Guardians designated RHP Luis Oviedo for assignment. |
| 05/20/22 | Cleveland Guardians optioned SS Richie Palacios to Columbus Clippers. |
| 05/16/22 | Cleveland Guardians transferred RHP James Karinchak from the 10-day injured list to the 60-day injured list. Right back strain. |
| 05/16/22 | Seattle Mariners traded RHP Yohan Ramirez to Cleveland Guardians. |
| 05/13/22 | Cleveland Guardians placed 1B Josh Naylor on the 10-day injured list retroactive to May 12, 2022. |
| 05/13/22 | Cleveland Guardians activated SS Yu Chang. |
| 05/13/22 | Cleveland Guardians placed 1B Josh Naylor on the 10-day injured list retroactive to May 12, 2022. |
| 05/13/22 | Cleveland Guardians recalled SS Richie Palacios from Columbus Clippers. |
| 05/13/22 | Cleveland Guardians optioned LHP Kirk McCarty to Columbus Clippers. |
| 05/09/22 | Cleveland Guardians optioned LHP Konnor Pilkington to Columbus Clippers. |
| 05/09/22 | Cleveland Guardians selected the contract of RHP Enyel De Los Santos, and from Columbus Clippers. |
| 05/08/22 | Cleveland Guardians reassigned RHP Enyel De Los Santos to the minor leagues. |
| 05/08/22 | RHP Enyel De Los Santos returned to Columbus Clippers from Cleveland Guardians. |
| 05/08/22 | Cleveland Guardians optioned SS Richie Palacios to Columbus Clippers. |
| 05/08/22 | Cleveland Guardians recalled LHP Konnor Pilkington from Columbus Clippers. |
| 05/08/22 | Cleveland Guardians optioned RHP Anthony Castro to Columbus Clippers. |
| 05/08/22 | Cleveland Guardians selected the contract of LHP Kirk McCarty from Columbus Clippers. |
| 05/07/22 | Cleveland Guardians recalled RHP Anthony Castro from Columbus Clippers. |
| 05/05/22 | Cleveland Guardians optioned RHP Anthony Castro to Columbus Clippers. |
| 05/05/22 | Baltimore Orioles claimed LHP Logan Allen off waivers from Cleveland Guardians. |
| 05/05/22 | Cleveland Guardians sent 1B Bobby Bradley outright to Columbus Clippers. |
| 05/04/22 | Cleveland Guardians recalled RHP Anthony Castro from Columbus Clippers. |
| 05/03/22 | Cleveland Guardians sent SS Yu Chang on a rehab assignment to Columbus Clippers. |
| 05/03/22 | Cleveland Guardians signed free agent LF Anthony Alford to a minor league contract. |
| 05/02/22 | Cleveland Guardians designated LHP Logan Allen for assignment. |
| 05/02/22 | Cleveland Guardians designated 1B Bobby Bradley for assignment. |
| 05/02/22 | Cleveland Guardians optioned RHP Anthony Castro to Columbus Clippers. |