Indians Roster & Staff
Transactions
| Date | Transaction |
| 04/17/21 | Cleveland Indians recalled LHP Sam Hentges from Indians Alternate Training Site. |
| 04/17/21 | Cleveland Indians optioned RF Ben Gamel to Indians Alternate Training Site. |
| 04/14/21 | Cleveland Indians signed free agent C Rene Rivera. |
| 04/03/21 | Cleveland Indians signed free agent C Gianpaul Gonzalez. |
| 04/03/21 | Cincinnati Reds claimed C Beau Taylor off waivers from Cleveland Indians. |
| 04/01/21 | RHP Triston McKenzie changed number to 24. |
| 04/01/21 | P Triston McKenzie changed number to 42. |
| 04/01/21 | P Cal Quantrill changed number to 42. |
| 04/01/21 | P Cal Quantrill changed number to 38. |
| 04/01/21 | P Bryan Shaw changed number to 27. |
| 04/01/21 | RHP Cal Quantrill changed number to 47. |
| 04/01/21 | RHP Bryan Shaw changed number to 27. |
| 04/01/21 | P Trevor Stephan changed number to 37. |
| 04/01/21 | RHP Trevor Stephan changed number to 37. |
| 04/01/21 | P Triston McKenzie changed number to 26. |
| 04/01/21 | P Trevor Stephan changed number to 42. |
| 04/01/21 | P Bryan Shaw changed number to 42. |
