The Halos' slugger joins Barry Bonds (762), Hank Aaron (755), Babe Ruth (714), Alex Rodriguez (696), Willie Mays (660), Ken Griffey Jr. (630), Jim Thome (612) and Sammy Sosa (609) as the only set of players to ever hit as many homers in the Major Leagues.
Pujols said he felt relieved after finally reaching the achievement, as he had been pressing in recent at-bats with the milestone just one connection away.
He also credited his wife, Deidre, who texted him during the game and told him to treat it like any other at-bat.
"Before I hit the home run, she told me, 'You need to stay back and just look for a pitch to hit!'" he said. "I'm glad that I listened to her."
When he stepped up to bat in a two-out, bases-loaded situation on the cusp of No. 600, the tension perhaps would have been felt ten-fold. But Pujols said he was as relaxed as he had been since hitting No. 599 against Atlanta on May 31; he was simply trying to get a good pitch to hit and knock a base hit.
"Really in that at-bat, I was really calm," he said. "I didn't know I was going to hit it out, but I knew I was going to have a good at-bat, because it was a different feeling than the first two at-bats that I had, and I was able to put a good swing on that slider."
At 37 years and 138 days old, Pujols is the fourth-youngest to hit 600 career home runs. He could very well see his name rise higher in the all-time ranks, but he insists he doesn't concern himself with numbers.
"I'm just glad to be on that list," he said. "It's a pretty special feeling. You look at all the players that come through the league, to play so long to be No. 9 -- it's pretty special.
"Don't get me wrong; it's an honor and privilege to be named in the same list and same sentence with those guys, but I really try to stay focused on my goal, and that's to go and be the best teammate I can be. And hopefully, help this organization to win. That's the truth."
Kaelen Jones is a reporter for MLB.com based in Los Angeles.