OAKLAND -- One rough inning was enough to snap A's lefty Sean Manaea's winning streak Wednesday night.
The Astros used five singles to score three runs off Manaea in the sixth in the A's 5-1 loss at the Coliseum. It was the left-hander's first loss in more than a month, with his last coming in his first start off the disabled list on May 15.
"They just got on him a little bit, and made him work," manager Bob Melvin said. "Probably not as good with his command that inning, and they squared some balls up. They're pretty good about being timely when they get their hits, and they were often."
Manaea was sharp through five innings, allowing just two hits and throwing only 70 pitches. But in the sixth, Jose Altuve led off with a single, his first hit in 14 career at-bats against Manaea. Carlos Correa followed with a single, advancing to second on the throw as Altuve moved to third.
Evan Gattis broke the scoreless tie with a two-run single. Manaea looked to avoid further damage after notching a pair of strikeouts, but Jake Marisnick hit an RBI single to left.
On his 29th pitch of the inning, Manaea struck out Norichika Aoki to end the inning -- and his night.
"Just getting behind hitters, and getting into hitter's counts and 3-2 counts. It just kind of snowballed," Manaea said. "I just didn't do a good job of containing things. It led to some 0-2 hits, and it's eventually what ended up giving up those three runs."

Manaea had eight strikeouts, but took his fourth loss of the season. He had won five of his last six starts prior to this outing.
"He's pitched well since he's come back from the DL. Almost every time, he gave up three runs [or less], so a lot of times, you're going to win games," Melvin said. "When you get three or four hits and you only score one run, you're not giving him much of a chance. But it's not like he pitched poorly."

Manaea said he felt the loss was "completely on me."
"There's a lot of things I need to get better at, and definitely one of them is to keep my emotions in check and finishing off hitters, and keeping things from snowballing to worse things," Manaea said. "I felt like I didn't do my job tonight."