Chris Iannetta, slated to start the game on the bench, replaced Cruz at DH.
"Neck issue… thing he came in with this morning, don't think he can go," Servais said of Gutierrez. "I would say it's a one-day thing, but I'm not sure yet. We have a day off tomorrow. [Francisco] Liriano and [Gerrit] Cole is what it's looking like [against Pittsburgh], so hopefully he's available."
Gutierrez is hitting .242 with six doubles, nine home runs and 25 RBIs in 63 games this season.
Dhiren Mahiban is a contributor to MLB.com based in Toronto.