BALTIMORE -- Los Angeles rookie Griffin Canning was a victim of the long ball on Sunday, giving up three home runs in the Angels’ 5-1 loss to the Orioles at Camden Yards.

Canning (1-1) gave up solo homers to Chris Davis and Stevie Wilkerson in the second inning and a two-run shot to Dwight Smith Jr. in the third.

“I thought he threw alright. Obviously the long ball hurt him,” manager Brad Ausmus said. “They didn’t get a bunch of hits off him, but the bulk of them were home runs.”

The right-hander allowed four runs on five hits and four walks in 4 2/3 innings while striking out six.

“I don’t think I was very sharp today, but I don’t expect to have my best stuff every single time, so it’s something I need to work through,” said Canning, who allowed two runs in 5 1/3 innings in his previous start, a win against the Detroit Tigers. “I made some good pitches, but they definitely jumped on the mistakes.”

He has 19 strikeouts through his first three starts, which ties Shohei Ohtani (2018) and Tim Fortugno (1992) for the franchise record. The Angels' second-round pick in the ‘17 Draft, Canning is ranked as the 55th best prospect in baseball by MLB Pipeline.

Canning struggled with his slider on Sunday, but said he liked his curveball and threw a couple of good changeups, a pitch he’s been working on.

“The home run to Smith was one [changeup] that just kind of straightened out, but it’s getting a lot more consistent,” Canning said.

Davis and Wilkerson homered on fastballs.

Canning’s best inning may have been the fifth, when he struck out Trey Mancini and Davis before a walk to Rio Ruiz ended his day after 101 pitches, 15 more than his previous high.

“Well a little bit was out of necessity,” Ausmus said of the pitch count. “Just in terms of bullpen usage and having guys available, not only being able to use guys today but having guys available tomorrow.”

“I’m doing my best to save the arms in the bullpen and not have those guys get in that early,” Canning said. “So I definitely wanted to finish off strong, finish that fifth inning.”

Mike Trout hit his ninth homer of the season for the Los Angeles run. It was his 10th homer in 28 career games at Camden Yards.

Los Angeles managed just four hits off Orioles left-hander John Means (5-3) and three relievers. The Angels (4-11) have the most losses in MLB when opposing a left-handed starter.

“I can’t explain it,” Ausmus said of the Angels record versus lefties. “It happened last year. I’m hoping it’s just noise and it’ll turn around, but I can’t give you an answer.”

Los Angeles had two men on with one out against Means in the first inning, but Albert Pujols and Kole Calhoun popped out. The Angels hit into three double plays, with Andrelton Simmons hitting into a pair, giving him 12 on the season.

“I feel like that pace should slow down a bit,” Ausmus said. “The one thing I say about double plays, you’re normally -- especially with a guy like Simmons -- hitting the ball hard on the ground for them to turn it. So he’s probably hitting the ball pretty hard, it’s just going at someone.”

The Angels won the first two games and were looking to sweep a three-game series in Baltimore for the first time since Sept. 6-8, 2002.