The defending World Series champion Cubs clash with the first-place Nationals when right-handers John Lackey and Stephen Strasburg duel in the District as part of a full slate of games, streaming live on MLB.TV.
The first two games of the series provided plenty of action and excitement, and the fun continues tonight as both clubs look to make waves in the National League standings.
Strasburg was cruising before meeting the Braves on June 12, but he has been unable to complete six innings in each of his past three starts. The 28-year-old righty will try to get back on track after surrendering 13 runs over his past 15 1/3 frames.
Lackey had lost four straight decisions before holding the Pirates in check on June 18, allowing just one run over six innings in the Cubs' 7-1 victory. He pitched well on Friday out, too, hurling six frames and giving up two runs (one earned) in a 2-0 loss to the Marlins.
First pitch is scheduled for 7:05 p.m. ET.
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Here's what else to watch for throughout the day (all times in ET):
Battle in Beantown: MIN@BOS, 7:10 p.m.
Two of the American League's best clubs meet when the Twins take on the Red Sox in Boston on Wednesday night.
Reigning AL Cy Young Award winner Rick Porcello has struggled to keep opposing teams off the scoreboard, as evidenced by his 5.00 ERA, but he is giving the Red Sox length. Porcello has lasted at least six innings in 15 of his 16 starts this year.
Minnesota turns to Adalberto Mejia, who is coming off his second win of the season after holding the Indians scoreless over five innings on Friday.

Nifty Nova: TB@PIT, 7:05 p.m.
Few pitchers in the Majors have been as consistent as the Pirates' Ivan Nova in 2017. The 30-year-old Nova has completed at least six frames in all 15 of his starts this year and hasn't allowed more than four runs in any outing.
The Rays welcome left-hander Blake Snell back to the rotation after optioning him to Triple-A Durham after his start on May 13. Snell, who went 0-4 with a 4.71 ERA in eight outings for Tampa Bay earlier this year, recorded a 2.66 ERA over 44 innings in his stint with the Bulls.

Dazzling Darvish: TEX@CLE, 7:10 p.m.
The Rangers' Yu Darvish was absolutely marvelous in his last outing on Friday, a no-decision against the Yankees in which he fanned 10 batters in seven scoreless frames and permitted just two batters to reach base. He will look to build on his success when he toes the rubber against the reigning AL champion Indians.
Cleveland hands the ball to right-hander Trevor Bauer, who pitched into the seventh inning in each of his previous two starts, the first time he has done so in consecutive appearances this year.

Return of Rodon: NYY@CWS, 8:10 p.m.
Former White Sox first-round Draft pick Carlos Rodon is scheduled to make his season debut against Masahiro Tanaka and the Yankees after a lengthy recovery from left biceps bursitis.
Rodon, who is expected to be activated from the 60-day disabled list, is 18-16 with a 3.90 ERA in 54 games (51 starts) across two seasons in the Majors.
Tanaka toes the rubber opposite Rodon following an outstanding, eight-inning scoreless start against the Rangers on Friday in which he allowed just three hits and two walks while striking out nine. The righty has racked up 27 strikeouts over his last three outings as he attempts to turn a corner.

Crosstown rivalry: LAD@LAA, 10:07 p.m.
The Dodgers and Angels go head-to-head in an intriguing Interleague matchup between crosstown rivals. Left-hander Hyun-Jin Ryu (3-6, 4.30 ERA) takes the mound for the Dodgers coming off back-to-back starts in which he completed five innings of two-run ball.
Righty Alex Meyer (3-4, 4.20 ERA) gets the ball for the Angels looking to bounce back from a loss to Boston when he surrendered five runs in 3 1/3 frames. He will try to replicate his outing from a few days prior when he held the Royals scoreless over six innings while striking out nine.