Twins Roster & Staff
Transactions
| Date | Transaction |
| 05/31/22 | Minnesota Twins sent RHP Jorge Alcala on a rehab assignment to Fort Myers Mighty Mussels. |
| 05/31/22 | Minnesota Twins placed SS Carlos Correa on the 10-day injured list. |
| 05/31/22 | Minnesota Twins recalled RHP Cole Sands from St. Paul Saints. |
| 05/31/22 | Minnesota Twins selected the contract of SS Jermaine Palacios from St. Paul Saints. |
| 05/30/22 | Minnesota Twins activated SS Jose Miranda. |
| 05/30/22 | Minnesota Twins activated SS Jose Miranda. |
| 05/30/22 | Philadelphia Phillies traded RF John Andreoli to Minnesota Twins. |
| 05/30/22 | Minnesota Twins recalled SS Jose Miranda and from St. Paul Saints. |
| 05/29/22 | Minnesota Twins placed SS Royce Lewis on the 10-day injured list. Right knee bone bruise. |
| 05/29/22 | Minnesota Twins recalled SS Royce Lewis from St. Paul Saints. |
| 05/29/22 | Minnesota Twins optioned SS Jose Miranda to St. Paul Saints. |
| 05/28/22 | Minnesota Twins placed LHP Danny Coulombe on the 15-day injured list. Left hip impingement. |
| 05/28/22 | Minnesota Twins optioned RHP Yennier Cano to St. Paul Saints. |
| 05/28/22 | Minnesota Twins selected the contract of RHP Juan Minaya from St. Paul Saints. |
| 05/28/22 | Minnesota Twins recalled LHP Jovani Moran from St. Paul Saints. |
| 05/27/22 | Minnesota Twins activated LHP Danny Coulombe. |
| 05/27/22 | Minnesota Twins placed CF Gilberto Celestino on the 10-day injured list. |
| 05/26/22 | Minnesota Twins signed free agent RHP Juan Mercedes to a minor league contract. |
| 05/25/22 | Minnesota Twins placed RHP Joe Ryan on the 10-day injured list. |
| 05/25/22 | Minnesota Twins recalled LHP Devin Smeltzer from St. Paul Saints. |
| 05/25/22 | Baltimore Orioles claimed RHP Chris Vallimont off waivers from Minnesota Twins. |
| 05/24/22 | Minnesota Twins signed free agent RHP Hunter Wood to a minor league contract. |
| 05/24/22 | Minnesota Twins sent LHP Danny Coulombe on a rehab assignment to St. Paul Saints. |
| 05/22/22 | Minnesota Twins activated OF Trevor Larnach. |
| 05/22/22 | Minnesota Twins sent LHP Danny Coulombe on a rehab assignment to Wichita Wind Surge. |
| 05/22/22 | Minnesota Twins placed RHP Cody Stashak on the 15-day injured list. Right shoulder impingement. |
| 05/21/22 | Minnesota Twins designated RHP Chris Vallimont for assignment. |
| 05/21/22 | Minnesota Twins placed RHP Josh Winder on the 15-day injured list retroactive to May 18, 2022. Right shoulder impingement. |
| 05/21/22 | Minnesota Twins activated RHP Bailey Ober. |
| 05/21/22 | Minnesota Twins optioned LHP Devin Smeltzer to St. Paul Saints. |
| 05/21/22 | Minnesota Twins selected the contract of RHP Trevor Megill from St. Paul Saints. |
| 05/20/22 | Minnesota Twins signed free agent RHP Tanner Gaff to a minor league contract. |
| 05/19/22 | Minnesota Twins sent RHP Jharel Cotton outright to St. Paul Saints. |
| 05/18/22 | Minnesota Twins activated SS Carlos Correa from the 10-day injured list. |
| 05/18/22 | Minnesota Twins optioned SS Royce Lewis to St. Paul Saints. |
| 05/17/22 | Minnesota Twins activated RHP Dylan Bundy from the 10-day injured list. |
| 05/17/22 | Minnesota Twins designated RHP Jharel Cotton for assignment. |
| 05/16/22 | Minnesota Twins activated RF Kyle Garlick. |
| 05/16/22 | Minnesota Twins optioned OF Mark Contreras to St. Paul Saints. |
| 05/14/22 | Minnesota Twins sent RHP Bailey Ober on a rehab assignment to St. Paul Saints. |
| 05/14/22 | Minnesota Twins transferred 3B Miguel Sano from the 10-day injured list to the 60-day injured list. |
| 05/14/22 | Minnesota Twins optioned RF Alex Kirilloff to St. Paul Saints. |
| 05/14/22 | Minnesota Twins selected the contract of LHP Devin Smeltzer from St. Paul Saints. |
| 05/13/22 | Minnesota Twins sent RF Kyle Garlick on a rehab assignment to St. Paul Saints. |
| 05/13/22 | Minnesota Twins optioned RHP Cole Sands to St. Paul Saints. |
| 05/12/22 | Minnesota Twins activated 2B Luis Arraez from the 10-day injured list. |
| 05/12/22 | Minnesota Twins transferred RHP Chris Paddack from the 15-day injured list to the 60-day injured list. |
| 05/12/22 | Minnesota Twins transferred RHP Chris Paddack from the 15-day injured list to the 60-day injured list. Right elbow inflammation. |
| 05/12/22 | Minnesota Twins transferred RHP Chris Paddack from the 15-day injured list to the 60-day injured list. |
| 05/12/22 | Minnesota Twins optioned C Jose Godoy to St. Paul Saints. |
| 05/12/22 | Minnesota Twins recalled RHP Cole Sands from St. Paul Saints. |
| 05/11/22 | Minnesota Twins placed LHP Danny Coulombe on the 15-day injured list. Left hip impingement. |
| 05/11/22 | Minnesota Twins transferred RHP Jhon Romero from the 10-day injured list to the 60-day injured list. |
| 05/11/22 | Minnesota Twins selected the contract of RHP Yennier Cano from St. Paul Saints. |
| 05/10/22 | Minnesota Twins placed SS Carlos Correa on the 10-day injured list retroactive to May 6, 2022. Right middle finer contusion. |
| 05/10/22 | Minnesota Twins placed RHP Chris Paddack on the 15-day injured list retroactive to May 9, 2022. Right elbow inflammation. |
| 05/10/22 | Minnesota Twins selected the contract of OF Mark Contreras from St. Paul Saints. |
| 05/10/22 | Minnesota Twins selected the contract of RHP Jharel Cotton from St. Paul Saints. |
| 05/08/22 | Minnesota Twins placed OF Trevor Larnach on the 10-day injured list. |
| 05/08/22 | Minnesota Twins recalled C Jose Godoy from St. Paul Saints. |
| 05/07/22 | Minnesota Twins activated RHP Sonny Gray. |
| 05/07/22 | Minnesota Twins optioned RHP Cole Sands to St. Paul Saints. |
| 05/06/22 | Minnesota Twins placed 2B Luis Arraez on the 10-day injured list. |
| 05/06/22 | Minnesota Twins placed RHP Dylan Bundy on the 10-day injured list. |
| 05/06/22 | Minnesota Twins activated RF Alex Kirilloff. |
| 05/06/22 | Minnesota Twins optioned LHP Jovani Moran to St. Paul Saints. |
| 05/06/22 | Minnesota Twins recalled RHP Cole Sands from St. Paul Saints. |
| 05/06/22 | Minnesota Twins recalled SS Royce Lewis from St. Paul Saints. |
| 05/03/22 | Minnesota Twins signed free agent LHP Cesar Lares to a minor league contract. |
| 05/02/22 | Minnesota Twins placed 3B Miguel Sano on the 10-day injured list retroactive to May 1, 2022. Left knee sprain. |
| 05/02/22 | Minnesota Twins placed RF Kyle Garlick on the 10-day injured list. Right calf strain. |
| 05/02/22 | Minnesota Twins optioned C Jose Godoy to St. Paul Saints. |
| 05/02/22 | Minnesota Twins recalled LHP Jovani Moran from St. Paul Saints. |
| 05/02/22 | Minnesota Twins recalled SS Jose Miranda from St. Paul Saints. |
| 05/02/22 | Minnesota Twins optioned RHP Cole Sands to St. Paul Saints. |
| 05/01/22 | Minnesota Twins sent RHP Sonny Gray on a rehab assignment to Fort Myers Mighty Mussels. |