Twins Roster & Staff
Transactions
| Date | Transaction |
| 08/31/22 | Minnesota Twins sent RHP Cole Sands on a rehab assignment to St. Paul Saints. |
| 08/31/22 | Minnesota Twins sent RHP Cole Sands on a rehab assignment to St. Paul Saints. |
| 08/31/22 | Minnesota Twins signed free agent RHP Brad Peacock to a minor league contract. |
| 08/31/22 | Minnesota Twins claimed LHP Austin Davis off waivers from Boston Red Sox. |
| 08/29/22 | Minnesota Twins optioned LHP Devin Smeltzer to St. Paul Saints. |
| 08/29/22 | Minnesota Twins recalled LHP Jovani Moran from St. Paul Saints. |
| 08/29/22 | Minnesota Twins sent SS Tim Beckham outright to St. Paul Saints. |
| 08/28/22 | Minnesota Twins sent RHP Randy Dobnak on a rehab assignment to St. Paul Saints. |
| 08/28/22 | Minnesota Twins sent RHP Randy Dobnak on a rehab assignment to St. Paul Saints. |
| 08/27/22 | Minnesota Twins signed free agent CF Billy Hamilton to a minor league contract. |
| 08/26/22 | Minnesota Twins designated SS Tim Beckham for assignment. |
| 08/26/22 | Minnesota Twins activated RF Kyle Garlick from the 10-day injured list. |
| 08/25/22 | Minnesota Twins signed free agent RHP Michael Feliz to a minor league contract. |
| 08/24/22 | Minnesota Twins sent RF Kyle Garlick on a rehab assignment to St. Paul Saints. |
| 08/24/22 | Minnesota Twins placed RHP Cole Sands on the 15-day injured list. Right elbow contusion. |
| 08/24/22 | Minnesota Twins recalled LHP Devin Smeltzer from St. Paul Saints. |
| 08/23/22 | Minnesota Twins placed CF Byron Buxton on the 10-day injured list. Low grade right hip strain. |
| 08/23/22 | Minnesota Twins sent RHP Randy Dobnak on a rehab assignment to Fort Myers Mighty Mussels. |
| 08/23/22 | Minnesota Twins transferred RF Alex Kirilloff from the 10-day injured list to the 60-day injured list. |
| 08/23/22 | Minnesota Twins recalled CF Caleb Hamilton from St. Paul Saints. |
| 08/23/22 | Minnesota Twins selected the contract of RHP Aaron Sanchez from St. Paul Saints. |
| 08/23/22 | Minnesota Twins optioned LHP Devin Smeltzer to St. Paul Saints. |
| 08/20/22 | Minnesota Twins recalled LHP Devin Smeltzer from St. Paul Saints. |
| 08/19/22 | Minnesota Twins signed free agent RHP Jordan Brink to a minor league contract. |
| 08/17/22 | Minnesota Twins optioned RHP Jake Jewell to St. Paul Saints. |
| 08/17/22 | Minnesota Twins claimed RHP Jake Jewell off waivers from Cleveland Guardians. |
| 08/15/22 | Minnesota Twins sent RHP Randy Dobnak on a rehab assignment to FCL Twins. |
| 08/15/22 | Minnesota Twins sent RHP Randy Dobnak on a rehab assignment to FCL Twins. |
| 08/15/22 | Minnesota Twins sent RHP Randy Dobnak on a rehab assignment to FCL Twins. |
| 08/10/22 | Minnesota Twins signed free agent LHP Jacob Edwards to a minor league contract. |
| 08/10/22 | Minnesota Twins signed free agent RHP Ricky Mineo to a minor league contract. |
| 08/10/22 | Minnesota Twins signed free agent SS Omari Daniel to a minor league contract. |
| 08/10/22 | Minnesota Twins signed free agent RHP Jack Noble to a minor league contract. |
| 08/08/22 | Minnesota Twins signed free agent RHP John Klein to a minor league contract. |
| 08/07/22 | Minnesota Twins released RHP Tyler Duffey. |
| 08/06/22 | Minnesota Twins activated RF Max Kepler from the 10-day injured list. |
| 08/06/22 | Minnesota Twins optioned OF Mark Contreras to St. Paul Saints. |
| 08/05/22 | Minnesota Twins designated RHP Tyler Duffey for assignment. |
| 08/05/22 | Minnesota Twins released RHP Joe Smith. |
| 08/05/22 | Minnesota Twins activated LHP Caleb Thielbar from the 15-day injured list. |
| 08/05/22 | Minnesota Twins activated LHP Caleb Thielbar from the 15-day injured list. |
| 08/05/22 | Minnesota Twins sent RHP Jharel Cotton outright to St. Paul Saints. |
| 08/05/22 | Pittsburgh Pirates claimed C Jose Godoy off waivers from Minnesota Twins. |
| 08/05/22 | Minnesota Twins sent RHP Aaron Sanchez outright to St. Paul Saints. |
| 08/05/22 | Minnesota Twins recalled OF Mark Contreras and from St. Paul Saints. |
| 08/05/22 | Minnesota Twins recalled RHP Cole Sands from St. Paul Saints. |
| 08/04/22 | Minnesota Twins placed RF Kyle Garlick on the 10-day injured list retroactive to August 2, 2022. Right ribcage contusion. |
| 08/04/22 | Minnesota Twins activated CF Gilberto Celestino from the paternity list. |
| 08/04/22 | Minnesota Twins activated RHP Tyler Mahle. |
| 08/04/22 | Minnesota Twins optioned LHP Jovani Moran to St. Paul Saints. |
| 08/03/22 | Minnesota Twins activated LHP Caleb Thielbar from the 15-day injured list. |
| 08/03/22 | Minnesota Twins activated C Sandy Leon. |
| 08/03/22 | Minnesota Twins designated RHP Joe Smith for assignment. |
| 08/03/22 | Minnesota Twins optioned CF Caleb Hamilton to St. Paul Saints. |
| 08/03/22 | Minnesota Twins optioned LHP Jovani Moran to St. Paul Saints. |
| 08/03/22 | Minnesota Twins selected the contract of C Sandy Leon from St. Paul Saints. |
| 08/02/22 | Minnesota Twins activated CF Jake Cave. |
| 08/02/22 | Minnesota Twins transferred 3B Miguel Sano from the 10-day injured list to the 60-day injured list. Left knee inflammation. |
| 08/02/22 | Minnesota Twins activated RHP Jorge López. |
| 08/02/22 | Minnesota Twins designated RHP Aaron Sanchez for assignment. |
| 08/02/22 | Minnesota Twins designated RHP Jharel Cotton for assignment. |
| 08/02/22 | Cincinnati Reds traded RHP Tyler Mahle to Minnesota Twins for SS Spencer Steer, 3B Christian Encarnacion-Strand and LHP Steve Hajjar. |
| 08/02/22 | Baltimore Orioles traded RHP Jorge Lopez and cash to Minnesota Twins for RHP Yennier Cano, LHP Cade Povich, LHP Juan Rojas and RHP Juan Nunez. |
| 08/02/22 | Baltimore Orioles traded RHP Jorge Lopez and cash to Minnesota Twins for RHP Yennier Cano, LHP Cade Povich, LHP Juan Rojas and RHP Juan Nunez. |
| 08/02/22 | Cincinnati Reds traded RHP Tyler Mahle to Minnesota Twins for SS Spencer Steer, 3B Christian Encarnacion-Strand and LHP Steve Hajjar. |
| 08/02/22 | Cleveland Guardians traded C Sandy Leon to Minnesota Twins for RHP Ian Hamilton. |
| 08/02/22 | Cleveland Guardians traded C Sandy Leon to Minnesota Twins for RHP Ian Hamilton. |
| 08/02/22 | Cincinnati Reds traded RHP Tyler Mahle to Minnesota Twins for SS Spencer Steer, 3B Christian Encarnacion-Strand and LHP Steve Hajjar. |
| 08/02/22 | Detroit Tigers traded RHP Michael Fulmer to Minnesota Twins for RHP Sawyer Gipson-Long. |
| 08/02/22 | Detroit Tigers traded RHP Michael Fulmer to Minnesota Twins for RHP Sawyer Gipson-Long. |
| 08/02/22 | Baltimore Orioles traded RHP Jorge Lopez and cash to Minnesota Twins for RHP Yennier Cano, LHP Cade Povich, LHP Juan Rojas and RHP Juan Nunez. |
| 08/02/22 | Baltimore Orioles traded RHP Jorge Lopez and cash to Minnesota Twins for RHP Yennier Cano, LHP Cade Povich, LHP Juan Rojas and RHP Juan Nunez. |
| 08/02/22 | Baltimore Orioles traded RHP Jorge Lopez and cash to Minnesota Twins for RHP Yennier Cano, LHP Cade Povich, LHP Juan Rojas and RHP Juan Nunez. |
| 08/02/22 | Cincinnati Reds traded RHP Tyler Mahle to Minnesota Twins for SS Spencer Steer, 3B Christian Encarnacion-Strand and LHP Steve Hajjar. |
| 08/02/22 | Minnesota Twins selected the contract of CF Jake Cave from St. Paul Saints. |
| 08/01/22 | Minnesota Twins designated C Jose Godoy for assignment. |
| 08/01/22 | Minnesota Twins activated 3B Gio Urshela from the paternity list. |
| 08/01/22 | Minnesota Twins placed CF Gilberto Celestino on the paternity list. |
| 08/01/22 | Minnesota Twins optioned RHP Yennier Cano to St. Paul Saints. |
| 08/01/22 | Minnesota Twins selected the contract of RHP Aaron Sanchez from St. Paul Saints. |