Guardians Roster & Staff
Transactions
| Date | Transaction |
| 06/28/10 | Cleveland Indians sent Shane Lindsay outright to Akron Aeros. |
| 06/28/10 | Cleveland Indians optioned CF Ezequiel Carrera to Columbus Clippers. |
| 06/27/10 | Cleveland Indians Traded 1B Russell Branyan to Seattle Mariners; High Desert Mavericks Traded SS Juan Diaz to Kinston Indians and Seattle Mariners Traded CF Ezequiel Carrera to Cleveland Indians. |
| 06/27/10 | Cleveland Indians Traded 1B Russell Branyan to Seattle Mariners; High Desert Mavericks Traded SS Juan Diaz to Kinston Indians and Seattle Mariners Traded CF Ezequiel Carrera to Cleveland Indians. |
| 06/27/10 | Cleveland Indians activated 1B Matt LaPorta. |
| 06/27/10 | Cleveland Indians recalled Matt LaPorta from Columbus Clippers. |
| 06/26/10 | Cleveland Indians signed LHP Kyle Petter. |
| 06/25/10 | Cleveland Indians claimed Jayson Nix off waivers from Chicago White Sox. |
| 06/25/10 | Cleveland Indians optioned Jensen Lewis to Columbus Clippers. |
| 06/25/10 | Cleveland Indians optioned Luis Valbuena to Columbus Clippers. |
| 06/25/10 | C Franklin Moreno assigned to DSL Indians from Cleveland Indians. |
| 06/25/10 | Cleveland Indians recalled Aaron Laffey from Columbus Clippers. |
| 06/25/10 | Cleveland Indians designated Shane Lindsay for assignment. |
| 06/22/10 | Aaron Siliga assigned to AZL Indians from Cleveland Indians. |
| 06/22/10 | Clayton Ehlert assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/22/10 | Cleveland Indians recalled Joe Smith from Columbus Clippers. |
| 06/22/10 | Cleveland Indians activated RHP Joe Smith. |
| 06/21/10 | 2B Logan Thompson assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Juan Romero assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Ryan Gardner assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | RHP Jose Lopez assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Felix Sterling assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Anthony Gallas assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Henry Dunn assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Nick Bartolone assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Luis Encarnacion assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | C Miguel Fuentes assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | RHP Matthew Speake assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Robel Garcia assigned to AZL Indians from Cleveland Indians. |
| 06/21/10 | Cleveland Indians optioned David Huff to Columbus Clippers. |
| 06/21/10 | Cleveland Indians signed OF Aaron Siliga. |
| 06/21/10 | Cleveland Indians signed RHP Clayton Ehlert. |
| 06/20/10 | Cleveland Indians signed free agent RHP Felix Sterling to a minor league contract. |
| 06/20/10 | Cleveland Indians signed IF Nick Bartolone. |
| 06/20/10 | Cleveland Indians signed 2B Logan Thompson. |
| 06/20/10 | Cleveland Indians signed OF Henry Dunn. |
| 06/20/10 | Cleveland Indians signed free agent OF Anthony Gallas to a minor league contract. |
| 06/20/10 | Cleveland Indians signed free agent 3B Juan Romero to a minor league contract. |
| 06/20/10 | Cleveland Indians signed free agent SS Robel Garcia to a minor league contract. |
| 06/20/10 | Cleveland Indians signed free agent C Miguel Fuentes to a minor league contract. |
| 06/20/10 | Cleveland Indians signed free agent RHP Jose Lopez to a minor league contract. |
| 06/20/10 | Cleveland Indians signed free agent RHP Ryan Gardner to a minor league contract. |
| 06/20/10 | Cleveland Indians signed free agent RHP Luis Encarnacion to a minor league contract. |
| 06/19/10 | Cleveland Indians traded 3B Adam Davis to Pittsburgh Pirates. |
| 06/18/10 | Owen Dew assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/18/10 | Tyler Cannon assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Cleveland Indians signed RHP Owen Dew. |
| 06/17/10 | Brian Heere assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Jordan Casas assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Aaron Fields assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Chase Burnette assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Jordan Cooper assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | C Diego Seastrunk assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Cleveland Indians signed SS Tyler Cannon. |
| 06/17/10 | RHP Casey Gaynor assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Andrew Kinney assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | J.D. Reichenbach assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/17/10 | Alex Kaminsky assigned to Mahoning Valley Scrappers from Cleveland Indians. |
| 06/16/10 | Cleveland Indians signed RHP Casey Gaynor. |
| 06/16/10 | Cleveland Indians signed free agent LHP J.D. Reichenbach to a minor league contract. |
| 06/16/10 | Cleveland Indians signed free agent 1B Andrew Kinney to a minor league contract. |
| 06/16/10 | Cleveland Indians signed OF Jordan Casas. |
| 06/16/10 | Cleveland Indians signed RHP Matthew Speake. |
| 06/14/10 | Cleveland Indians signed OF Chase Burnette. |
| 06/13/10 | Cleveland Indians signed OF Brian Heere. |
| 06/13/10 | Cleveland Indians signed RHP Alex Kaminsky. |
| 06/12/10 | Cleveland Indians signed 2B Aaron Fields. |
| 06/12/10 | Cleveland Indians signed RHP Jordan Cooper. |
| 06/12/10 | Cleveland Indians signed C Diego Seastrunk. |
| 06/11/10 | Cleveland Indians recalled Carlos Santana from Columbus Clippers. |
| 06/11/10 | Cleveland Indians optioned Lou Marson to Columbus Clippers. |
| 06/08/10 | Cleveland Indians selected the contract of SS Anderson Hernandez from Columbus Clippers. |
| 06/08/10 | Cleveland Indians designated 2B Mark Grudzielanek for assignment. |
| 06/07/10 | Andy Marte roster status changed by Cleveland Indians. |
| 06/07/10 | Cleveland Indians optioned Matt LaPorta to Columbus Clippers. |
| 06/04/10 | Cleveland Indians selected the contract of Frank Herrmann from Columbus Clippers. |
| 06/04/10 | Cleveland Indians designated RHP Jamey Wright for assignment. |
| 06/01/10 | Cleveland Indians optioned Shane Lindsay to Kinston Indians. |
| 06/01/10 | Cleveland Indians transferred CF Grady Sizemore from the 15-day disabled list to the 60-day disabled list. |
| 06/01/10 | Cleveland Indians claimed RHP Shane Lindsay off waivers from New York Yankees. |