Guardians Roster & Staff
Transactions
| Date | Transaction |
| 04/29/22 | Cleveland Guardians sent SS Yu Chang on a rehab assignment to Akron RubberDucks. |
| 04/29/22 | Cleveland Guardians sent SS Yu Chang on a rehab assignment to Akron RubberDucks. |
| 04/28/22 | Cleveland Guardians sent RHP Anthony Castro on a rehab assignment to Columbus Clippers. |
| 04/26/22 | Cleveland Guardians claimed RHP Luis Oviedo off waivers from Pittsburgh Pirates. |
| 04/25/22 | Cleveland Guardians activated C Luke Maile. |
| 04/25/22 | Cleveland Guardians optioned C Bryan Lavastida to Columbus Clippers. |
| 04/25/22 | LHP Kirk McCarty returned to Columbus Clippers from Cleveland Guardians. |
| 04/25/22 | Cleveland Guardians recalled SS Richie Palacios from Columbus Clippers. |
| 04/24/22 | Cleveland Guardians activated SS Owen Miller from the 10-day injured list. |
| 04/24/22 | Cleveland Guardians optioned LHP Konnor Pilkington to Columbus Clippers. |
| 04/23/22 | Cleveland Guardians activated RHP Cal Quantrill from the 10-day injured list. |
| 04/23/22 | LHP Tanner Tully returned to Columbus Clippers from Cleveland Guardians. |
| 04/22/22 | Cleveland Guardians signed free agent C Alex Paredes to a minor league contract. |
| 04/21/22 | Cleveland Guardians recalled SS Gabriel Arias and from Columbus Clippers. |
| 04/21/22 | Cleveland Guardians optioned SS Gabriel Arias to Columbus Clippers. |
| 04/20/22 | Cleveland Guardians selected the contract of LHP Kirk McCarty from Columbus Clippers. |
| 04/20/22 | Cleveland Guardians selected the contract of RHP Enyel De Los Santos from Columbus Clippers. |
| 04/20/22 | Cleveland Guardians selected the contract of LHP Tanner Tully from Columbus Clippers. |
| 04/15/22 | Cleveland Guardians sent C Luke Maile on a rehab assignment to Columbus Clippers. |
| 04/15/22 | 1B Josh Naylor roster status changed by Cleveland Guardians. |
| 04/15/22 | Cleveland Indians placed SS Yu Chang on the 10-day injured list. |
| 04/15/22 | Cleveland Guardians optioned LHP Konnor Pilkington to Columbus Clippers. |
| 04/15/22 | Cleveland Guardians recalled LHP Konnor Pilkington from Columbus Clippers. |
| 04/14/22 | Cleveland Guardians optioned LHP Konnor Pilkington to Columbus Clippers. |
| 04/12/22 | Cleveland Guardians signed free agent RHP Jogly Garcia to a minor league contract. |
| 04/09/22 | Cleveland Guardians activated RHP Anthony Castro. |
| 04/09/22 | Cleveland Guardians placed RHP Anthony Castro on the 10-day injured list. |
| 04/09/22 | Cleveland Guardians activated RHP Anthony Castro. |
| 04/09/22 | Cleveland Guardians activated RHP Anthony Castro. |
| 04/08/22 | Cleveland Guardians traded CF Bradley Zimmer to Toronto Blue Jays for RHP Anthony Castro. |
| 04/08/22 | Cleveland Guardians traded CF Bradley Zimmer to Toronto Blue Jays for RHP Anthony Castro. |
| 04/05/22 | C Manuel Mejias and assigned to Cleveland Guardians. |
| 04/05/22 | C Wilmer Hernandez and assigned to Cleveland Guardians. |
| 04/05/22 | LHP Skylar Arias assigned to Cleveland Guardians. |
| 04/05/22 | RHP Liam Jenkins and assigned to Cleveland Guardians. |
| 04/05/22 | RHP Tyler Thornton and assigned to Cleveland Guardians. |
| 04/05/22 | OF Johnathan Rodriguez and assigned to Cleveland Guardians. |
| 04/05/22 | SS Maick Collado and assigned to Cleveland Guardians. |
| 04/05/22 | OF Daniel Aguilar and assigned to Cleveland Guardians. |
| 04/05/22 | RHP Damon Casetta-Stubbs and assigned to Cleveland Guardians. |
| 04/05/22 | LHP Skylar Arias roster status changed by Cleveland Guardians. |
| 04/05/22 | SS Angel Genao and assigned to Cleveland Guardians. |
| 04/04/22 | Cleveland Guardians activated LHP Logan Allen. |
| 04/04/22 | Cleveland Guardians placed C Luke Maile on the 10-day injured list. Strained left hamstring. |
| 04/04/22 | Cleveland Guardians activated OF Steven Kwan. |
| 04/04/22 | Cleveland Guardians activated C Bryan Lavastida. |
| 04/04/22 | Cleveland Guardians activated C Bryan Lavastida. |
| 04/04/22 | Cleveland Guardians activated OF Steven Kwan. |
| 04/04/22 | Cleveland Guardians placed RHP James Karinchak on the 10-day injured list. Right back strain. |
| 04/04/22 | Cleveland Guardians activated C Bryan Lavastida. |
| 04/04/22 | Cleveland Guardians activated OF Steven Kwan. |
| 04/04/22 | Cleveland Guardians activated LHP Konnor Pilkington. |
| 04/04/22 | Cleveland Guardians placed 1B Josh Naylor on the 10-day injured list. Recovery from fractured right ankle. |
| 04/03/22 | RHP Alec Wisely and assigned to Cleveland Guardians. |
| 04/03/22 | C Angel Lopez Alvarez and assigned to Cleveland Guardians. |
| 04/03/22 | OF Alexfri Planez and assigned to Cleveland Guardians. |
| 04/02/22 | C Cesar Idrogo and assigned to Cleveland Guardians. |
| 04/02/22 | C Micael Ramirez and assigned to Cleveland Guardians. |
| 04/02/22 | Cleveland Guardians optioned RHP Tobias Myers to Columbus Clippers. |
| 04/01/22 | C Miguel Jerez and assigned to Cleveland Guardians. |
| 04/01/22 | SS Jordan Brown and assigned to Cleveland Guardians. |
| 04/01/22 | CF Quentin Holmes and assigned to Cleveland Guardians. |