Twins Roster & Staff
Transactions
| Date | Transaction |
| 01/27/22 | Minnesota Twins signed free agent SS Bryan Acuna to a minor league contract. |
| 01/24/22 | Minnesota Twins signed free agent OF Elijah Greene to a minor league contract. |
| 01/21/22 | Minnesota Twins signed free agent RHP Leonardo Lugo to a minor league contract. |
| 01/16/22 | Minnesota Twins signed free agent SS Kevin Merrell to a minor league contract. |
| 01/16/22 | Minnesota Twins signed free agent OF Anderson Nova to a minor league contract. |
| 01/15/22 | Minnesota Twins signed free agent RHP Ledwin Taveras to a minor league contract. |
| 01/15/22 | Minnesota Twins signed free agent 2B Harold Grant to a minor league contract. |
| 01/15/22 | Minnesota Twins signed free agent 2B Juan Zapata to a minor league contract. |
| 01/15/22 | Minnesota Twins signed free agent OF Yasser Mercedes to a minor league contract. |
| 01/15/22 | Minnesota Twins signed free agent OF Jose Rodriguez to a minor league contract. |
| 01/15/22 | Minnesota Twins signed free agent SS Yilber Herrera to a minor league contract. |
| 01/12/22 | Minnesota Twins signed free agent RHP Matt Mullenbach to a minor league contract. |
| 01/11/22 | Minnesota Twins signed free agent RHP Dereck Rodriguez to a minor league contract. |
| 01/10/22 | Minnesota Twins signed free agent C Collin Hopkins to a minor league contract. |
| 01/08/22 | Minnesota Twins signed free agent C Alex Rodriguez to a minor league contract. |
| 01/04/22 | Minnesota Twins signed free agent CF Kennie Taylor to a minor league contract. |
| 01/04/22 | Minnesota Twins signed free agent RHP Mario Sanchez to a minor league contract. |
| 01/04/22 | Minnesota Twins signed free agent RHP Orlando Rodriguez to a minor league contract. |
| 01/02/22 | Minnesota Twins signed free agent RHP Jeferson Lopez to a minor league contract. |