Guardians Roster & Staff
Transactions
| Date | Transaction |
| 09/28/09 | Cleveland Indians signed RHP Nietzer Jimenez. |
| 09/28/09 | Cleveland Indians signed SS Richard Delgado. |
| 09/28/09 | Cleveland Indians signed C Juan De La Cruz. |
| 09/28/09 | Cleveland Indians signed RHP Yan Caripa. |
| 09/28/09 | Cleveland Indians signed C Franklin Moreno. |
| 09/28/09 | Cleveland Indians signed LHP Jonathan Cedeno. |
| 09/28/09 | Cleveland Indians signed RHP Juan Santana. |
| 09/28/09 | Cleveland Indians signed RHP Amiro Santana. |
| 09/28/09 | Cleveland Indians signed SS Jorge Martinez. |
| 09/28/09 | Cleveland Indians signed SS Jairo Kelly. |
| 09/28/09 | Cleveland Indians signed LHP Alexander Joseph. |
| 09/28/09 | Cleveland Indians signed OF Angel Hernandez. |
| 09/28/09 | Cleveland Indians signed C Gustavo Rojas. |
| 09/28/09 | Cleveland Indians signed RHP Alejandro Rivas. |
| 09/23/09 | Cleveland Indians sent Zach Jackson outright to Columbus Clippers. |
| 09/23/09 | Cleveland Indians sent R.J. Swindle outright to Columbus Clippers. |
| 09/23/09 | Cleveland Indians sent Rich Rundles outright to Columbus Clippers. |
| 09/14/09 | Cleveland Indians placed RHP Joe Smith on the 15-day disabled list. Sprained left knee. |
| 09/11/09 | Cleveland Indians placed CF Grady Sizemore on the 15-day disabled list retroactive to September 4, 2009. Recovering from left elbow surgery. |
| 09/08/09 | Cleveland Indians selected the contract of Niuman Romero from Columbus Clippers. |
| 09/07/09 | Cleveland Indians recalled Lou Marson from Columbus Clippers. |
| 09/04/09 | Trevor Crowe roster status changed by Cleveland Indians. |
| 09/04/09 | Cleveland Indians selected the contract of Mike Gosling from Columbus Clippers. |
| 09/01/09 | Cleveland Indians recalled Carlos Carrasco from Columbus Clippers. |
| 09/01/09 | Cleveland Indians selected the contract of RHP Jose Veras from Columbus Clippers. |
| 09/01/09 | RHP Yohan Pino assigned to Columbus Clippers from Cleveland Indians. |
| 09/01/09 | Cleveland Indians selected the contract of Michael Brantley from Columbus Clippers. |