Guardians Roster & Staff
Transactions
| Date | Transaction |
| 07/31/21 | Cleveland Guardians activated RF Myles Straw. |
| 07/31/21 | Cleveland Indians designated RHP Justin Garza for assignment. |
| 07/31/21 | Cleveland Indians recalled RHP Justin Garza from Columbus Clippers. |
| 07/30/21 | Cleveland Indians traded LF Jordan Luplow and RHP DJ Johnson to Tampa Bay Rays for RHP Peyton Battenfield. |
| 07/30/21 | Cleveland Indians traded LF Jordan Luplow and RHP DJ Johnson to Tampa Bay Rays for RHP Peyton Battenfield. |
| 07/30/21 | Cleveland Indians traded LF Jordan Luplow and RHP DJ Johnson to Tampa Bay Rays for RHP Peyton Battenfield. |
| 07/30/21 | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| 07/30/21 | Cleveland Indians traded LF Eddie Rosario and cash to Atlanta Braves for 3B Pablo Sandoval. |
| 07/30/21 | Cleveland Indians traded LF Eddie Rosario and cash to Atlanta Braves for 3B Pablo Sandoval. |
| 07/30/21 | Cleveland Indians released 3B Pablo Sandoval. |
| 07/30/21 | Cleveland Indians recalled SS Owen Miller from Columbus Clippers. |
| 07/30/21 | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| 07/30/21 | Cleveland Indians placed 1B Bobby Bradley on the bereavement list. |
| 07/30/21 | Cleveland Indians traded RHP Phil Maton and C Yainer Diaz to Houston Astros for RF Myles Straw. |
| 07/29/21 | Cleveland Indians traded 2B Cesar Hernandez to Chicago White Sox for LHP Konnor Pilkington. |
| 07/29/21 | Cleveland Indians traded 2B Cesar Hernandez to Chicago White Sox for LHP Konnor Pilkington. |
| 07/28/21 | Cleveland Indians activated RHP Cam Hill. |
| 07/28/21 | Cleveland Indians optioned RHP Cam Hill to Columbus Clippers. |
| 07/26/21 | Cleveland Indians placed RHP Aaron Civale on the 60-day injured list. Sprained right middle finger. |
| 07/26/21 | Cleveland Indians claimed LHP Alex Young off waivers from Arizona Diamondbacks. |
| 07/25/21 | Cleveland Indians placed RHP Shane Bieber on the 60-day injured list. Right shoulder sub scapularis strain. |
| 07/24/21 | Cleveland Indians signed RHP Tommy Ventimiglia. |
| 07/24/21 | Cleveland Indians signed RHP Tyler Thornton. |
| 07/24/21 | Cleveland Indians signed LHP Doug Nikhazy. |
| 07/24/21 | Cleveland Indians signed LHP Rodney Boone. |
| 07/24/21 | Cleveland Indians signed free agent C Seth Caddell to a minor league contract. |
| 07/24/21 | Cleveland Indians signed RHP Tommy Mace. |
| 07/24/21 | Cleveland Indians signed SS Jake Fox. |
| 07/24/21 | Cleveland Indians signed LHP Will Dion. |
| 07/24/21 | Cleveland Indians signed RHP Franco Aleman. |
| 07/24/21 | Cleveland Indians signed RHP Trenton Denholm. |
| 07/24/21 | Cleveland Indians signed RHP Alaska Abney. |
| 07/24/21 | Cleveland Indians signed RHP Gavin Williams. |
| 07/24/21 | Cleveland Indians signed RHP Aaron Davenport. |
| 07/24/21 | Cleveland Indians signed OF Connor Kokx. |
| 07/24/21 | Cleveland Indians signed LHP Ryan Webb. |
| 07/24/21 | Cleveland Indians signed RHP Tanner Bibee. |
| 07/24/21 | Cleveland Indians signed RHP Hunter Stanley. |
| 07/24/21 | Cleveland Indians signed RHP Davis Sharpe. |
| 07/24/21 | Cleveland Indians signed RHP Jack Leftwich. |
| 07/24/21 | Cleveland Indians signed RHP Reid Johnston. |
| 07/24/21 | Cleveland Indians signed RHP Zach Pettway. |
| 07/22/21 | Cleveland Guardians recalled LHP Sam Hentges, and from Columbus Clippers. |
| 07/22/21 | Cleveland Indians optioned RHP Eli Morgan to Columbus Clippers. |
| 07/21/21 | Cleveland Indians recalled SS Yu Chang from Columbus Clippers. |
| 07/21/21 | Cleveland Indians optioned RHP Justin Garza to Columbus Clippers. |
| 07/20/21 | Cleveland Indians sent LF Jordan Luplow on a rehab assignment to Columbus Clippers. |
| 07/19/21 | Cleveland Indians recalled RHP J.C. Mejia from Columbus Clippers. |
| 07/19/21 | Cleveland Indians optioned RHP DJ Johnson to Columbus Clippers. |
| 07/12/21 | Cleveland Indians sent LF Jordan Luplow on a rehab assignment to ACL Indians. |
| 07/09/21 | Cleveland Indians optioned LHP Sam Hentges to Columbus Clippers. |
| 07/09/21 | Seattle Mariners traded RHP Damon Casetta-Stubbs to Cleveland Indians. |
| 07/09/21 | Cleveland Indians recalled RHP Triston McKenzie from Columbus Clippers. |
| 07/08/21 | Cleveland Guardians activated RHP Zach Plesac. |
| 07/08/21 | Cleveland Indians optioned RHP J.C. Mejia to Columbus Clippers. |
| 07/08/21 | Cleveland Indians optioned SS Owen Miller to Columbus Clippers. |
| 07/08/21 | Cleveland Indians released C Rene Rivera. |
| 07/07/21 | Cleveland Indians selected the contract of RHP DJ Johnson from Columbus Clippers. |
| 07/07/21 | Cleveland Indians recalled RF Daniel Johnson from Columbus Clippers. |
| 07/07/21 | Cleveland Indians recalled SS Owen Miller from Columbus Clippers. |
| 07/07/21 | Cleveland Indians placed 1B Josh Naylor on the 60-day injured list. Right ankle fracture. |
| 07/07/21 | Cleveland Indians placed LF Eddie Rosario on the 10-day injured list. Right abdominal strain. |
| 07/06/21 | Cleveland Indians signed free agent C Wilson Ramos to a minor league contract. |
| 07/06/21 | Cleveland Indians optioned LHP Logan Allen to Columbus Clippers. |
| 07/03/21 | Cleveland Indians designated C Rene Rivera for assignment. |
| 07/03/21 | Cleveland Indians activated C Roberto Perez. |
| 07/02/21 | Cleveland Indians sent C Roberto Perez on a rehab assignment to Columbus Clippers. |
| 07/02/21 | Cleveland Guardians activated RF Franmil Reyes. |
| 07/02/21 | Cleveland Indians optioned SS Yu Chang to Columbus Clippers. |
| 07/01/21 | Cleveland Indians optioned SS Owen Miller to Columbus Clippers. |