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DraftKings picks: Seager, Harper, De Aza

With several skilled starters scheduled to take the mound Saturday, making hitter choices will be a difficult task for DraftKings participants. The best strategy, for some, may be to stack lineups against the few subpar starters on the docket and pay for premium arms. With this approach in mind, DraftKings participants should consider the following players:

Kyle Seager (Mariners): The owner of a career .805 OPS vs. right-handers (.665 vs. lefties), Seager matches up well with Rangers righty Colby Lewis, who as a big leaguer has allowed left-handed hitters such as Seager to post a collective .828 OPS.

Seth Smith (Mariners): Smith -- who owns a career .840 OPS vs. right-handers as opposed to a .605 mark vs. lefties -- is another left-handed-hitting masher who could fare well against Lewis. The outfielder typically hits high in the lineup against right-handers, which will maximize his opportunities to produce for DraftKings participants on Saturday.

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Brad Miller (Mariners): DraftKings participants could create a stack laden with Mariners infielders by combining Robinson Cano, Seager and Miller. With a .721 OPS vs. right-handers (.596 against lefties) during his big league tenure, the shortstop will likely hit low in the lineup, but he should still get chances to capitalize on a favorable matchup with Lewis.

Bryce Harper (Nationals): Harper has slugged 46 of his 57 career homers against right-handers, and he owns a lifetime .864 OPS in those matchups (.704 vs. lefties). The outfielder could go deep on Saturday, when he faces the Phillies' fly-ball-prone right-hander, Aaron Harang.

Chris Davis (Orioles): The first baseman has compiled a career .849 OPS vs. right-handers (.728 against lefties), and he could homer at hitter-friendly Fenway Park against Clay Buchholz, who has posted a 7.84 ERA through his first two 2015 starts after finishing last season with a 5.34 mark.

Adam Jones (Orioles): Jones is another O's hitter who could find success against Buchholz. With a lifetime.283/.320/.477 slash line against right-handers, the outfielder is a candidate to reach base multiple times and display extra-base power.

Alejandro De Aza (Orioles): DraftKings participants who wish to use an Orioles stack on Saturday would be wise to include De Aza, who owns a career .754 OPS vs. righties (.669 against southpaws). As the team's likely leadoff hitter, De Aza could reach base multiple times and put himself in position to be driven home by Jones and Davis.

David Ortiz (Red Sox): The designated hitter has handled right-handers to the tune of a career .972 OPS (.819 vs. lefties), and he could put a ball into the outfield seats when he faces Orioles righty Chris Tillman, who has a lifetime 1.3 HR/9 rate.

Jose Altuve (Astros): Altuve will bring his lifetime .882 OPS against lefties (.691 vs. right-handers) into a matchup with Angels southpaw C.J. Wilson on Saturday. The Angels' starter has allowed right-handed batters such as Altuve to compile a collective .726 OPS, much higher than Wilson's .550 mark allowed to left-handed hitters. Altuve swiped 56 bags last season, so he should get the green light to run if he reaches base against Wilson.

Evan Gattis (Astros): Mired in an early-season slump, this powerful catcher could be a cost-effective DraftKings option. On Saturday, Gattis will bring his career .851 OPS vs. lefties (.747 against right-handers) into a contest against Wilson and the Halos.

Lucas Duda (Mets): Duda has ripped 66 of his 75 career round-trippers against right-handers, which has helped him compile a lifetime .852 OPS in those matchups. On Saturday, the first baseman could succeed against Marlins righty Mat Latos, who lasted less than an inning in his 2015 debut before allowing eight baserunners across four frames during his last time out.

Curtis Granderson (Mets): Granderson has compiled a lifetime .855 OPS against right-handers (.707 vs. lefties), and he has produced 116 of his 131 career steals with a right-hander on the mound. On Saturday, he could reach base multiple times vs. Latos and swipe a bag against Marlins catcher Jarrod Saltalamacchia, who sometimes struggles to control the running game.

Felix Hernandez (Mariners): The right-hander has dealt with right quad tightness of late, but he is scheduled to start at home against Lewis and the Rangers on Saturday. After posting a 2.14 ERA and a 0.92 WHIP last season, Hernandez seemingly has a distinct advantage over Lewis, who registered a 5.18 ERA and a 1.52 WHIP in 2014.

Jordan Zimmermann (Nationals): Zimmermann struggled against the Red Sox his last time out, but he compiled a 2.66 ERA and a 1.07 WHIP last season and should be an effective starting option during most of his 2015 outings. On Saturday, he should get back on track in a return to his home park to face Harang (career 4.19 ERA), who is backed by an underwhelming Phillies offense.

Jacob deGrom (Mets): The 2014 National League Rookie of the Year is off to a fine start in 2015, and he should continue to post excellent numbers when he faces the Marlins at his home park on Saturday. The right-hander could come away with a win if his offense has success against the struggling Latos.

Jake Odorizzi (Rays): The fly-ball-prone right-hander has already excelled this season against the Blue Jays' and Orioles' powerful lineups, so he should be able to succeed at his pitcher-friendly home park against the Yankees on Saturday. Odorizzi could pick up a victory if he can outperform Masahiro Tanaka, who has compiled a 7.00 ERA across a pair of 2015 starts.

Chris Heston (Giants): After posting a 3.38 ERA and a 1.17 WHIP in Triple-A last year, Heston has allowed one earned run across two starts since replacing Matt Cain in the Giants' rotation to start the regular season. With the help of his pitcher-friendly home park, Heston could extend his early-season success by shutting down the D-backs on Saturday.

All statistics are accurate through the completion of Thursday's games.

Fred Zinkie is a senior fantasy baseball writer for Follow him on Twitter at @FredZinkieMLB.