Cubs Roster & Staff
Transactions
| Date | Transaction |
| 09/30/22 | Chicago Cubs sent RF Michael Hermosillo outright to Iowa Cubs. |
| 09/27/22 | Chicago Cubs activated C Willson Contreras from the 10-day injured list. |
| 09/27/22 | Chicago Cubs designated RF Michael Hermosillo for assignment. |
| 09/27/22 | Chicago Cubs activated OF Seiya Suzuki from the restricted list. |
| 09/27/22 | Chicago Cubs optioned 2B Jared Young to Iowa Cubs. |
| 09/21/22 | Chicago Cubs activated RHP Keegan Thompson from the 15-day injured list. |
| 09/21/22 | Chicago Cubs optioned RHP Jeremiah Estrada to Iowa Cubs. |
| 09/20/22 | Chicago Cubs placed OF Seiya Suzuki on the restricted list. |
| 09/20/22 | Chicago Cubs sent LHP Steven Brault on a rehab assignment to Iowa Cubs. |
| 09/19/22 | Chicago Cubs sent LHP Sean Newcomb outright to Iowa Cubs. |
| 09/18/22 | Chicago Cubs released 1B Frank Schwindel. |
| 09/17/22 | Chicago Cubs designated LHP Sean Newcomb for assignment. |
| 09/17/22 | Chicago Cubs designated 1B Frank Schwindel for assignment. |
| 09/17/22 | Chicago Cubs placed OF Seiya Suzuki on the paternity list. |
| 09/17/22 | Chicago Cubs activated RHP Adbert Alzolay from the 60-day injured list. |
| 09/17/22 | Chicago Cubs selected the contract of 3B Esteban Quiroz from Iowa Cubs. |
| 09/16/22 | Chicago Cubs sent RHP Keegan Thompson on a rehab assignment to Iowa Cubs. |
| 09/15/22 | Chicago Cubs signed free agent C David Avitia to a minor league contract. |
| 09/14/22 | Chicago Cubs placed LF Rafael Ortega on the 60-day injured list. Right ring finger fracture. |
| 09/14/22 | Chicago Cubs selected the contract of 2B Jared Young from Iowa Cubs. |
| 09/10/22 | Chicago Cubs activated 3B Patrick Wisdom from the 10-day injured list. |
| 09/10/22 | Chicago Cubs activated 3B Patrick Wisdom from the 10-day injured list. |
| 09/09/22 | Chicago Cubs sent RHP Kervin Castro outright to Iowa Cubs. |
| 09/09/22 | Cincinnati Reds claimed RHP Luke Farrell off waivers from Chicago Cubs. |
| 09/09/22 | Chicago White Sox claimed RHP Nicholas Padilla off waivers from Chicago Cubs. |
| 09/06/22 | Chicago Cubs designated RHP Nicholas Padilla for assignment. |
| 09/06/22 | Chicago Cubs activated RF Michael Hermosillo from the 60-day injured list. |
| 09/06/22 | Chicago Cubs placed C Willson Contreras on the 10-day injured list retroactive to September 3, 2022. Left ankle sprain. |
| 09/06/22 | Chicago Cubs activated LHP Wade Miley from the 60-day injured list. |
| 09/06/22 | Chicago Cubs designated RHP Luke Farrell for assignment. |
| 09/05/22 | Chicago Cubs placed LHP Justin Steele on the 15-day injured list retroactive to September 2, 2022. |
| 09/05/22 | Chicago Cubs activated RHP Hayden Wesneski. |
| 09/05/22 | Chicago Cubs activated RHP Hayden Wesneski. |
| 09/05/22 | Chicago Cubs designated RHP Kervin Castro for assignment. |
| 09/05/22 | Chicago Cubs selected the contract of RHP Hayden Wesneski from Iowa Cubs. |
| 09/01/22 | Chicago Cubs activated LHP Justin Steele from the restricted list. |
| 09/01/22 | Chicago Cubs placed LHP Wade Miley on the 60-day injured list. |
| 09/01/22 | Chicago Cubs activated RHP Adrian Sampson from the restricted list. |
| 09/01/22 | LHP Brendon Little roster status changed by Chicago Cubs. |
| 09/01/22 | Chicago Cubs recalled 2B David Bote from Iowa Cubs. |
| 09/01/22 | Chicago Cubs selected the contract of RHP Jeremiah Estrada from Iowa Cubs. |
| 09/01/22 | LHP Brendon Little returned to Iowa Cubs from Chicago Cubs. |
| 09/01/22 | RHP Jeremiah Estrada returned to Iowa Cubs from Chicago Cubs. |