Cubs Roster & Staff
Transactions
| Date | Transaction |
| 02/22/21 | Atlanta Braves claimed LF Phillip Ervin off waivers from Chicago Cubs. |
| 02/20/21 | Chicago Cubs sent SS Sergio Alcantara outright to Iowa Cubs. |
| 02/20/21 | Chicago Cubs designated LF Phillip Ervin for assignment. |
| 02/20/21 | Chicago Cubs signed free agent CF Jake Marisnick. |
| 02/18/21 | Chicago Cubs signed free agent P Brandon Workman. |
| 02/18/21 | Chicago Cubs designated SS Sergio Alcantara for assignment. |
| 02/17/21 | Chicago Cubs placed P Kyle Ryan on the 10 day disabled list. |
| 02/17/21 | Chicago Cubs signed free agent P Jake Arrieta. |
| 02/12/21 | Chicago Cubs signed free agent C Jose Lobaton to a minor league contract and invited him to spring training. |
| 02/12/21 | LHP Brendon Little assigned to Chicago Cubs. |
| 02/12/21 | Chicago Cubs signed free agent LHP Adam Morgan to a minor league contract and invited him to spring training. |
| 02/12/21 | Chicago Cubs invited non-roster 2B Trent Giambrone to spring training. |
| 02/12/21 | Chicago Cubs invited non-roster 1B Alfonso Rivas to spring training. |
| 02/12/21 | Chicago Cubs invited non-roster RHP Michael Rucker to spring training. |
| 02/12/21 | Chicago Cubs invited non-roster RHP Tommy Nance to spring training. |
| 02/12/21 | Chicago Cubs invited non-roster C P.J. Higgins to spring training. |
| 02/12/21 | Chicago Cubs invited non-roster RHP Trevor Megill to spring training. |
| 02/12/21 | Chicago Cubs signed free agent RHP Shelby Miller to a minor league contract and invited him to spring training. |
| 02/10/21 | Cincinnati Reds claimed 2B Max Schrock off waivers from Chicago Cubs. |
| 02/05/21 | Chicago Cubs signed free agent LF Joc Pederson. |
| 02/05/21 | Chicago Cubs signed free agent RHP Trevor Williams. |
| 02/05/21 | Chicago Cubs claimed SS Sergio Alcantara off waivers from Detroit Tigers. |
| 02/05/21 | Chicago Cubs designated 2B Max Schrock for assignment. |
| 02/05/21 | Chicago Cubs signed free agent LHP Andrew Chafin. |
