Kimbrel got Brandon Crawford on a first-pitch ground ball to second baseman Jedd Gyorko. The next batter, Gregor Blanco, actually saw two pitches, sending a 1-0 fastball in Gyorko's direction, a ground ball for the second out.
Finally, Kimbrel got pinch-hitter Hector Sanchez on a first-pitch fastball, a routine fly ball to Melvin Upton Jr. to end the game.
Four pitches, all fastballs, three outs.
"To do it in four pitches is nice," Kimbrel said. "It's nice to get in there and get my work in. I'm just trying to get ahead in the count and get out of there."
Kimbrel became the fourth pitcher in franchise history to earn a save in four pitches while also working one inning. Trevor Hoffman (2000, 2005) and Lance McCullers (1988) also did it.
For Kimbrel, it's the first time in his career he's worked such an efficient inning for a save. He previously earned saves covering one inning with seven pitches on five occasions.
He also earned a save in the team's fifth consecutive game, tying a franchise record set by Hoffman (1999), Mark Davis (1989) and Rollie Fingers (1977).
San Diego interim manager Pat Murphy was impressed.
"One too many pitches," he said, smiling. "It was really nice. He's throwing the ball good. And he didn't throw a breaking ball, either."
Kimbrel went into Tuesday's game with the Giants at Petco Park with the fifth-most saves in the National League. Since May 25, he's 15-for-15 in save opportunities with 29 strikeouts over 20 2/3 innings.